100390-63-4

Basic information

• Product Name: 4-[(acetylamino)methyl]benzyl acetate
• Synonyms: acetamide, N-[[4-[(acetyloxy)methyl]phenyl]methyl]-
• CAS NO: 100390-63-4
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.25
• Mol File: 100390-63-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.2°C at 760 mmHg
• Flash Point: 199.5°C
• Density: 1.12g/cm³
• Vapor Pressure: 8.28E-07mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 4-[(acetylamino)methyl]benzyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(acetylamino)methyl]benzyl acetate(100390-63-4)
• EPA Substance Registry System: 4-[(acetylamino)methyl]benzyl acetate(100390-63-4)

Safety Data

• Hazardous Substances Data: 100390-63-4(Hazardous Substances Data)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 39895-56-2 4-hydroxymethyl-benzylamine 
• 75-36-5 acetyl chloride 
• 1129-35-7 4-cyanobenzoic acid methyl ester 

Downstream Products

• 1192815-20-5 N-(4-(bromomethyl)benzyl)acetamide 
• 223512-41-2 N-(4-chloromethyl-benzyl)-acetamide 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.