100422-07-9Relevant academic research and scientific papers
1-[Hydroxy(sulfonyloxy)iodo]-2,2,2-trifluoroethanes, CF3CH2I(OH)OSO2R: Stable, fluoroalkyl analogs of Koser's reagent
Zhdankin, Viktor V.,Kuehl, Chris J.,Simonsen, Angela J.
, p. 2203 - 2206 (1995)
1-[Hydroxy(sulfonyloxy)iodo]-2,2,2-trifluoroethanes [CF3CH2I(OH)OSO2R; R = CH3, CF3, p-CH3C6H4] can be prepared in two steps from trifluoroethyliodide by oxidation with pertrifluoroacetic acid and subsequent reaction with TsOH, MsOH, or Me3SiOTf. Reaction of the tosylate derivative 3 with silyl enol ethers affords α-tosyloxyketones, while triflate 5 smoothly reacts with trimethylsilylbenzene to give the respective trifluoroethyl(phenyl)iodonium triflate 8.
Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization
Tolnai, Gergely L.,Székely, Anna,Makó, Zita,Gáti, Tamás,Daru, János,Bihari, Tamás,Stirling, András,Novák, Zoltán
, p. 4488 - 4491 (2015)
A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation. This journal is
Fluoroalkylaryliodonuim compounds
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, (2008/06/13)
Fluoroalkylaryliodonium compounds having the formula (I): STR1 wherein AR, A and Rf are as defined above, are disclosed. The fluoroalkylaryliodonium compounds of the present invention are useful as intermediates for producing N-fluoroalkylanilines or deri
