1004294-77-2

Usage

Uses

Used in Chemical Synthesis:
2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester is used as a reactant for the synthesis of trifluoroacetophenone-linked nucleotides and DNA. Its unique structure allows for the formation of stable and functional molecules that can be utilized in various research and development applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester is used as a key intermediate in the development of novel drugs. Its ability to form stable linkages with nucleotides and DNA makes it a valuable component in the design of new therapeutic agents targeting genetic and molecular pathways.
Used in Material Science:
2,2,2-Trifluoroacetophenone-4-boronic acid pinacol ester can also be employed in the field of material science, where its unique properties can be leveraged to create new materials with specific characteristics, such as enhanced stability, reactivity, or selectivity.

Upstream product

• 1426082-73-6 2,2,2-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanol 
• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1022154-88-6 2,2,2-trifluoro-1-[4-(5-fluoropyridin-2-yl)phenyl]ethanone 
• 875272-89-2 (S)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4’-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)ethyl)amino)pentanoic acid 

Relevant academic research and scientific papers

Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma

Growth, division, and development of healthy cells relies on efficient response to environmental survival cues. The conserved mitogen-activated protein kinase (MAPK) family of pathways interface extracellular stimuli to intracellular processes for this purpose. Within these pathways, the MEK family has been identified as a target of interest due to its clinical relevance. Particularly, MEK4 has drawn recent attention for its indications in pancreatic and prostate cancers. Here, we report two potent MEK4 inhibitors demonstrating significant reduction of phospho-JNK and antiproliferative properties against pancreatic cancer cell lines. Furthermore, molecular inhibition of MEK4 pathway activates the MEK1/2 pathway, with the combination of MEK1/2 and MEK4 inhibitors demonstrating synergistic effects against pancreatic cancer cells. Our inhibitors provided insight into the crosstalk between MAPK pathways and new tools for elucidating the roles of MEK4 in disease states, findings which will pave the way for better understanding of the MAPK pathways and development of additional probes.

Preparation method of odanacatib, and preparation method of odanacatib intermediate

The invention discloses a preparation method of odanacatib, and a preparation method of an odanacatib intermediate. The preparation method of the trifluoroethylketone biphenyl methylsulfone intermediate I comprises the following step: 2,2,2-trifluoro-1-[4

Organocatalytic Aerobic Oxidation of α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature

The organocatalytic aerobic oxidation of electron-deficient α-fluoroalkyl alcohols at room temperature is described. The resulting fluoroalkyl ketones are versatile synthetic intermediates for a variety of fluorine-containing molecules. This otherwise difficult transformation has now been accomplished by the reaction of α-fluoroalkyl alcohols with N-oxyl radicals, catalytically generated from 9-azabicyclo[3.3.1]nonan-3-one N-oxyl/nitrogen oxide (keto-ABNO/NOx) and oxygen in acetic acid (AcOH), affording the corresponding fluoroalkyl ketones in high yield. This operationally simple reaction can be performed under mild conditions, and was applied to a wide range of alcohols (20 examples), thus demonstrating a high functional group tolerance. Moreover, a modified one-pot protocol based on this method was able to convert an aldehyde to a trifluoromethyl ketone on a gram scale.

Substituted inmidazoles as bombesin receptor subtype-3 modulators

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.