100445-96-3

Usage

Chemical Properties

Brown Solid

Upstream product

• 100445-95-2 N-(3-hydroxy-2,6-dimethylphenyl)acetamide 
• 5416-12-6 N-(2,6-dimethyl-3-nitro-phenyl)acetamide 
• 7732-18-5 water 
• 39053-43-5 1-bromo-2,4-dimethyl-3-nitro-benzene 
• 81-20-9 2,6-dimethylnitrobenzene 
• 53874-26-3 3-bromo-2,6-dimethyl-aniline 
• 1427407-02-0 tert-butyl N-(3-hydroxy-2,6-dimethylphenyl)carbamate 
• 1427407-01-9 [3-(acetyl(tert-butoxycarbonyl)amino)-2,4-dimethylphenyl]tert-butyl carbonate 
• 87-62-7 2,6-dimethylaniline 
• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 

Downstream Products

• 1427407-04-2 3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-dimethylphenol 
• 1427407-05-3 ethyl 2-[3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-dimethyl-phenoxy]acetate 
• 1427406-10-7 2-[3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-2,4-dimethylphenoxy]acetic acid 
• 1427407-93-9 3-[[2-fluoro-5-(3-fluorophenyl)-3-methylphenyl]methylamino]-2,4-dimethylphenol 
• 1427407-94-0 C₂₇H₂₉F₂NO₃ 
• 1427406-34-5 C₂₄H₂₃F₂NO₃ 
• 1427406-37-8 C₂₆H₂₇F₂NO₃ 
• 1427408-03-4 3-[[3-(3-fluorophenyl)-5-methylphenyl]methylamino]-2,4-dimethylphenol 
• 1427408-04-5 C₂₇H₃₀FNO₃ 
• 1427406-49-2 C₂₄H₂₄FNO₃ 
• 1427408-06-7 3-[[5-(3-fluorophenyl)-2,3-dimethylphenyl]methylamino]-2,4-dimethylphenol 
• 1427408-07-8 C₂₈H₃₂FNO₃ 
• 1427406-50-5 C₂₅H₂₆FNO₃ 
• 1427408-09-0 3-[[5-(3-fluorophenyl)-2-methoxy-3-methylphenyl]methylamino]-2,4-dimethylphenol 

Relevant academic research and scientific papers

QUINAZOLINE COMPOUNDS

The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

Pyrrolizidine derivative and pharmaceutical composition thereof

A novel pyrrolizidine derivative of the formula, STR1 which has potent antiarrhythmic activity and low toxicity is produced. The derivative can be synthesized: by acylating 2,6-xylidine to protect the amino group, nitrating the protected xylidine to introduce a nitro group at 3-position, reducing the nitro group to an amino group, followed by diazotizing and hydrolyzing, and then the resulted 3-hydroxy-2,6-dimethylaniline being condensed with 8-halocarbonylmethylpyrrolizidine; or by nitrating N-(2',6'-dimethyl)phenyl-8-pyrrolizidineacetamide to introduce a nitro group at 3'-position, reducing the nitro group to amino group, diazotizing the amino group and hydrolyzing the diazonium compound.