53874-26-3Relevant academic research and scientific papers
INHIBITING HUMAN INTEGRIN α4β7
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, (2021/04/23)
Disclosed are small molecule antagonists of human α4β7 integrin, and methods of using them to treat a number of diseases and conditions.
BENZOTHIAZOL COMPOUNDS AND METHODS USING THE SAME FOR TREATING NEURODEGENERATIVE DISORDERS
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, (2019/04/18)
The present disclosure provides a compound of general Formula (I) having c-abl kinase inhibitory activity or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound, and a method useful to treat or prevent neurodegenerative diseases using the compound.
From Naproxen Repurposing to Naproxen Analogues and Their Antiviral Activity against Influenza A Virus
Dilly, Sébastien,Fotso Fotso, Aurélien,Lejal, Nathalie,Zedda, Gloria,Chebbo, Mohamad,Rahman, Fryad,Companys, Simon,Bertrand, Hélène C.,Vidic, Jasmina,Noiray, Magali,Alessi, Marie-Christine,Tarus, Bogdan,Quideau, Stéphane,Riteau, Béatrice,Slama-Schwok, Anny
, p. 7202 - 7217 (2018/08/01)
The nucleoprotein (NP) of influenza A virus (IAV) required for IAV replication is a promising target for new antivirals. We previously identified by in silico screening naproxen being a dual inhibitor of NP and cyclooxygenase COX2, thus combining antivira
QUINAZOLINE COMPOUNDS
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, (2015/06/11)
The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.
An electroluminescent compound and an electroluminescent device comprising the same
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, (2016/10/08)
The present invention relates to an organic light emitting compound represented by chemical formula 1, and an organic electroluminescent device comprising the same. The organic light emitting compound according to the present invention increases PL quantu
THIOPHENE-2-CARBOXAMIDE DERIVATIVES AS MODULATORS OF CCR9 RECEPTOR
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Page/Page column 39, (2009/05/29)
Provided are compounds of Formula (I) or of Formula (II) that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or amelioratin diseases associated with modulation of CCR9 receptor activity.
Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
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, (2008/06/13)
The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.
