5416-12-6

Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1625, 1983 DOI: 10.1021/jm00365a014

InChI:InChI=1/C10H12N2O3/c1-6-4-5-9(12(14)15)7(2)10(6)11-8(3)13/h4-5H,1-3H3,(H,11,13)

Upstream product

• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 67083-28-7 2,6-dimethyl-3-nitroaniline 
• 129319-10-4 3-bromo-2,6-dimethylacetanilide 
• 100445-95-2 N-(3-hydroxy-2,6-dimethylphenyl)acetamide 
• 1427406-55-0 C₂₄H₂₄FNO₄ 
• 1427406-54-9 C₂₃H₂₂FNO₄ 
• 1427408-22-7 C₂₆H₂₈FNO₄ 
• 1427408-21-6 C₂₇H₃₀FNO₄ 
• 1427408-20-5 3-[[3-(3-fluorophenyl)-5-methoxyphenyl]methylamino]-2,4-dimethylphenol 
• 1427408-19-2 3-(3-fluorophenyl)-N-(3-hydroxy-2,6-dimethylphenyl)-5-methoxybenzamide 
• 1427406-52-7 C₂₄H₂₃F₂NO₃ 
• 1427408-13-6 isopropyl 2-[3-[[2-fluoro-3-(3-fluorophenyl)-5-methylphenyl]methylamino]-2,4-dimethylphenoxy]acetate 
• 1427408-12-5 3-[[2-fluoro-3-(3-fluorophenyl)-5-methylphenyl]methylamino]-2,4-dimethylphenol 
• 1427408-11-4 2-fluoro-3-(3-fluorophenyl)-N-(3-hydroxy-2,6-dimethyl-phenyl)-5-methylbenzamide 
• 1427406-51-6 C₂₅H₂₆FNO₄ 

Relevant academic research and scientific papers

ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

The present invention relates to aniline derivatives, to their preparation and to their therapeutic application.

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Revisitation of Formaldehyde Aniline Condensation. VIII. - Monomeric N-Methylene Anilines

A convenient, high yield "dry" method of synthesis of monomeric N-methyleneanilines (6a-i) and the characterization of the products by m.s., 1H- and 13C-n.m.r. and i.r. are reported, improving previous procedures and describing new compounds.It appeared that the existence of monomeric N-methyleneanilines is stricly related to the presence of enough steric hindrance to oligomerization by substituents in ortho positions.Moreover, some addition products of formaldehyde to an amine and its corresponding imines are tentatively identified on the basis of the observed mass spectrum of the whole reaction mixture.The reaction products of formaldehyde with 2,6-dimethylaniline (1a) provided an example of a mobile equilibrium between monomeric and trimeric imine.

Pyrrolizidine derivative and pharmaceutical composition thereof

A novel pyrrolizidine derivative of the formula, STR1 which has potent antiarrhythmic activity and low toxicity is produced. The derivative can be synthesized: by acylating 2,6-xylidine to protect the amino group, nitrating the protected xylidine to introduce a nitro group at 3-position, reducing the nitro group to an amino group, followed by diazotizing and hydrolyzing, and then the resulted 3-hydroxy-2,6-dimethylaniline being condensed with 8-halocarbonylmethylpyrrolizidine; or by nitrating N-(2',6'-dimethyl)phenyl-8-pyrrolizidineacetamide to introduce a nitro group at 3'-position, reducing the nitro group to amino group, diazotizing the amino group and hydrolyzing the diazonium compound.