100476-63-9 Usage
General Description
1,3-Dihydro-3-((4-(2-benzoxazoyl)phenyl)imino)-1-(4-morpholinylmethyl) -2H-indol-2-one, also known as GW 537696X, is a chemical compound with potential pharmaceutical applications. It belongs to the class of indole derivatives and is being studied for its potential as an anti-cancer agent due to its ability to inhibit the growth of cancer cells. Additionally, it has shown anti-inflammatory and anti-angiogenic properties, making it a potential candidate for the treatment of various diseases. Its unique structure, which includes a benzoxazole and a morpholine ring, provides opportunities for further exploring its potential in drug development. Further research is needed to fully understand its pharmacological properties and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 100476-63-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,7 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100476-63:
(8*1)+(7*0)+(6*0)+(5*4)+(4*7)+(3*6)+(2*6)+(1*3)=89
89 % 10 = 9
So 100476-63-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H22N4O3/c31-26-24(20-5-1-3-7-22(20)30(26)17-29-13-15-32-16-14-29)27-19-11-9-18(10-12-19)25-28-21-6-2-4-8-23(21)33-25/h1-12H,13-17H2/b27-24-
100476-63-9Relevant articles and documents
Synthesis of Substituted 2-Phenylbenzoxazoles as CNS Active Agents
Varma, Rajendra S.,Chauhan, Sudha,Prasad, C. R.
, p. 280 - 285 (2007/10/02)
The reaction of hydrazine (III) with CS2 and ethanolic KOH furnishes 2--5-mercaptooxadiazole (IV) which on Mannich reaction with piperidine and morpholine gives the bases Va and Vb respectively.Condensation of isatin and 5-chloroisatin with III affords VI and VII which on Mannich reaction furnish the bases VIII and IX respectively.Condensation of N-methylisatin and N-methyl-5-chloroisatin with III gives X and XI.Treatment of 2-(p-hydroxyphenyl)benzoxazole (I) with allyl bromide furnishes the allyl derivative (XII) while acetylation of it with Ac2O gives XIII.Mannich reaction of benzothiazolin-2-thione, benzoxazolin-2-one and 6-nitrobenzoxazolin-2-one with 2-(p-aminophenyl)benzoxazole (XIV) affords the compounds XV, XVIa and XVIb, respectively.Treatment of acetanthranil (XVII) with XIV gives 3--2-methyl-4-quinazolone (XVIII).Condensation of isatin and N-methylisatin with XIV furnishes XIX and XX respectively.The former (XIX) on Mannich reaction with morpholine and formaldehyde gives rise to XXI.