20934-81-0

Usage

InChI:InChI=1/C13H10N2O/c14-10-7-5-9(6-8-10)13-15-11-3-1-2-4-12(11)16-13/h1-8H,14H2

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 95-55-6 2-amino-phenol 
• 840-58-4 2(4-nitrophenyl)benzoxazole 
• 2835-68-9 4-aminobenzamide 
• 583-53-9 2,3-dibromobenzene 
• 273-53-0 benzoxazole 
• 106-40-1 4-bromo-aniline 
• 16106-38-0 4-aminobenzoyl chloride 
• 109-86-4 2-methoxy-ethanol 
• 873-74-5 4-Aminobenzonitrile 
• 615-36-1 2-bromoaniline 
• 68005-30-1 2-bromo-1,3-benzoxazole 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 3164-13-4 2-(4-bromophenyl)-1,3-benzoxazole 

Downstream Products

• 16707-39-4 N-(4-benzooxazol-2-yl-phenyl)-succinamic acid 
• 100476-59-3 3-benzoxazolin-2-one 
• 100476-58-2 3-benzothiazoline-2-thinone 
• 29754-17-4 2-(p-benzamidophenyl)benzoxazole 
• 132194-99-1 bis(o-nitrobenzyl) 2,5-bis<carbamoyl>terephthalate 
• 195977-68-5 2-<4-(6-N-trifluoroacetylaminohexanoyl)aminophenyl>benzoxazole 
• 162374-61-0 -(4′-azidophenyl)benzoxazole 
• 27337-45-7 N-(4-(benzo[d]oxazol-2-yl)phenyl)acetamide 
• 733038-35-2 2-(4-amino-3-bromophenyl)benzoxazole 
• 195977-70-9 2-<4-(6-aminohexanoyl)aminophenyl>benzoxazole 
• 16707-46-3 (3R)-6ξ-[(4-benzooxazol-2-yl-phenylcarbamoyl)-methyl]-5-oxo-thiomorpholine-3r-carboxylic acid ethyl ester 
• 16707-43-0 N-(4-benzooxazol-2-yl-phenyl)-succinimide 
• 16707-41-8 N-(4-benzooxazol-2-yl-phenyl)-maleimide 
• 182274-80-2 N-(4-(1,3-benzothiazol-2-yl)phenyl)-2-chloroacetamide 

Relevant academic research and scientific papers

Biological evaluation of hepatitis C virus helicase inhibitors

A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the link

Synthesis and spectral studies of a novel benzoxazole-derived fluorescent probe for Hg2+

A novel turn-off fluorescent probe bearing a benzoxazole fluorophore has been synthesised and characterised. Its recognition properties towards different metal ions have been researched by spectrometry. The probe was highly selective and sensitive to Hgs

Crystal structures of benzoxazolyl-copper(iii,ii,i) complexes and investigation of Cu(ii)-mediated aryl carbon-hydrogen bromination

Copper complexes have been frequently involved in many Cu-mediated carbon-hydrogen halogenation reactions. We fortunately obtained three different valence benzoxazolyl-copper complexes, along with aryl carbon-hydrogen bromination, in the self-assembly reaction of ligands with CuBr2. The complexes have been successfully characterized by X-ray single crystal diffraction analyses. The results indicate that 1 consists of di-brominated p-benzoxazolylphenylamine (L) and an unusual high valence copper(iii) complex with tetrahedral geometry, 2 is the first polymeric catenulate di-brominated benzoxazolyl-copper(i) complex and 3 is the mono-brominated benzoxazolyl-copper(ii) complex. We speculate proposed mechanisms for the formation of these complexes and the bromination of aryl carbon-hydrogen based on these crystal structures. This journal is

Green, efficient and large-scale synthesis of benzimidazoles, benzoxazoles and benzothiazoles derivatives using ligand-free cobalt-nanoparticles: As potential anti-estrogen breast cancer agents, and study of their interactions with estrogen receptor by mo

A facile and high yielding method for the synthesis of 2-aryl benzoxazoles, benzimidazole and benzothiazoles is reported employing cobalt oxide nanoparticles. The cobalt oxide nanoparticles were used as a convenient, green, easy available and highly effic

Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory

Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having antioxidant potential were designed synthesized, characterized, and evalua

New benzothiazole/benzoxazole-pyrazole hybrids with potential as COX inhibitors: design, synthesis and anticancer activity evaluation

Ten new hybrids were designed and synthesized, their chemical structures were confirmed through spectral and elemental analysis. The new hybrids were screened against lung, breast and liver cancer cell lines (A549, MCF7 and Hep3B), in addition to normal f

A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a potential therapeutic target for the treatment of inflammatory diseases and certain types of cancer. To identify novel scaffolds for mPGES-1 inhibition, we applied a virtual screening (VS) p

Synthesis and fluorescence properties of benzoxazole-1,4-dihydropyridine dyads achieved by a multicomponent reaction

Photoactive 2-(2′-hydroxyphenyl)benzoxazole-1,4-dihydropyridine (HBO-DHP) dyads were obtained by a multicomponent one-pot Hantzsch synthesis using a fluorescent aldehyde, a 1,3-dicarbonylic compound and ammonium acetate. The key step in this synthetic methodology was the synthesis of the formyl benzoxazole derivative through a Duff-modified functionalization protocol. UV-Vis absorption and fluorescence emission spectroscopies were also applied to better understand the photophysics of these compounds. The three novel fluorescent compounds were obtained in moderate yields as stable solids with absorption in the UV region and emission in the blue-green region. Preliminary results indicate that after excitation both HBO and DHP fluorophores behave independently in the HBO-DHP structure. the Partner Organisations 2014.

Synthesis of some new benzoxazole derivatives and investigation of their anticancer activities

Phortress is an anticancer prodrug, which has active metabolite (5F-203) being potent agonist of the aryl hydrocarbon receptor (AhR). The 5F-203 switches on cytochrome P450 CYP1A1 gene expression and thus exhibits anticancer activity. In this study, it is

Tertiary amine derivatives and organic electroluminescent device including the same

A UV-region high-energy external light source is effectively absorbed to minimize damage to organic materials in the organic electroluminescent device. 1 Is a cross-sectional view of an organic electroluminescence device according to the present invention. O-2 electrode 1 Or more organic material layers disposed between the (2) and (1) th electrodes. A capping layer is included. The organic material layer and/or the capping layer may include the 1 st amine derivative represented by Formula 3. Chemical Formula 1. Wherein each substituent in Formula 1 is as defined in the description of the invention.