20934-81-0Relevant articles and documents
Biological evaluation of hepatitis C virus helicase inhibitors
Phoon, Chee Wee,Ng, Poh Yong,Ting, Anthony E.,Yeo, Su Ling,Sim, Mui Mui
, p. 1647 - 1650 (2001)
A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the link
Crystal structures of benzoxazolyl-copper(iii,ii,i) complexes and investigation of Cu(ii)-mediated aryl carbon-hydrogen bromination
Wang, Lianke,Zhou, Hongping,Wu, Jieying,Tian, Yupeng
, p. 9921 - 9926 (2015)
Copper complexes have been frequently involved in many Cu-mediated carbon-hydrogen halogenation reactions. We fortunately obtained three different valence benzoxazolyl-copper complexes, along with aryl carbon-hydrogen bromination, in the self-assembly reaction of ligands with CuBr2. The complexes have been successfully characterized by X-ray single crystal diffraction analyses. The results indicate that 1 consists of di-brominated p-benzoxazolylphenylamine (L) and an unusual high valence copper(iii) complex with tetrahedral geometry, 2 is the first polymeric catenulate di-brominated benzoxazolyl-copper(i) complex and 3 is the mono-brominated benzoxazolyl-copper(ii) complex. We speculate proposed mechanisms for the formation of these complexes and the bromination of aryl carbon-hydrogen based on these crystal structures. This journal is
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory
Srivastava, Pavan,Tripathi, Prabhash Nath,Sharma, Piyoosh,Rai, Sachchida Nand,Singh, Surya Pratap,Srivastava, Rakesh K.,Shankar, Sharmila,Shrivastava, Sushant K.
, p. 116 - 135 (2019)
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having antioxidant potential were designed synthesized, characterized, and evalua
A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors
Shekfeh, Suhaib,?al??kan, Burcu,Fischer, Katrin,Yal??n, Tansu,Garscha, Ulrike,Werz, Oliver,Banoglu, Erden
, p. 273 - 281 (2019)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a potential therapeutic target for the treatment of inflammatory diseases and certain types of cancer. To identify novel scaffolds for mPGES-1 inhibition, we applied a virtual screening (VS) p
Tertiary amine derivatives and organic electroluminescent device including the same
-
Paragraph 0144; 0145; 0149; 0150, (2021/06/01)
A UV-region high-energy external light source is effectively absorbed to minimize damage to organic materials in the organic electroluminescent device. 1 Is a cross-sectional view of an organic electroluminescence device according to the present invention. O-2 electrode 1 Or more organic material layers disposed between the (2) and (1) th electrodes. A capping layer is included. The organic material layer and/or the capping layer may include the 1 st amine derivative represented by Formula 3. Chemical Formula 1. Wherein each substituent in Formula 1 is as defined in the description of the invention.
An electroluminescent compound and an electroluminescent device comprising the same
-
Paragraph 0160; 0168-0170, (2020/12/15)
The present invention relates to an organic light emitting compound and an organic light emitting device employing the same, wherein the organic light emitting compound has excellent solubility in an organic solvent, thereby enabling a solution process during device manufacturing, and improving light emitting characteristics such as low voltage driving, luminous efficiency, long lifespan, etc. The present invention provides the organic light emitting compound represented by chemical formula I and capable of applying the solution process by having crosslinking properties.
Synthesis, photophysical characterization, CASSCF/CASPT2 calculations and CT-DNA interaction study of amino and azido benzazole analogues
Gil, Eduarda S.,da Silva, Cláudia B.,Nogara, Pablo A.,da Silveira, Carolina H.,da Rocha, Jo?o B.T.,Iglesias, Bernardo A.,Lüdtke, Diogo S.,Gon?alves, Paulo F.B.,Rodembusch, Fabiano S.
, (2019/11/26)
This work describes the synthesis and photophysical investigation of amino and azido benzazoles. The amino derivatives were obtained by condensation reaction between ortho-substituted anilines and p-aminobenzoic in polyphosphoric acid. The respective azides were synthesized by reaction of diazonium salts from the previously prepared amines with sodium azide. These compounds present absorption maxima in the UV-A region, nm ascribed to fully spin and symmetry electronic transitions. All compounds presented a main fluorescence emission in the UV-A to the violet region with a relatively large Stokes shift. The latter related to a solvent dependence. The amino derivatives presented higher values to the fluorescence quantum yields in despite of the azido analogues. DFT, TD-DFT and multiconfigurational calculations (SA-CASSCF and MS-CASPT2) were performed in order to investigate the photophysical features of these molecules, mainly on the azide derivatives, where the main interest was the investigation of the intrinsic fluorescence quenching present in these compounds. In this sense, it was observed that the weak fluorescence emission observed in the azide compounds could be related to the dissociative character of the S1 state, which reaches a conical intersection point between S1/S0 states, and through this point, goes back to the ground state by a nonradioactive decay. In addition, the DNA binding assays by UV–Vis absorption and fluorescence emission methodologies indicated that the benzazoles presented strong interaction with CT-DNA, which could be attributed to π-stacking and/or intermolecular hydrogen-bonding. Docking was also performed to better understand the observed interaction.
