1004794-09-5

Basic information

• Product Name: tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate
• CAS NO: 1004794-09-5
• Molecular Weight: 502.937
• Mol File: 1004794-09-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate(1004794-09-5)
• EPA Substance Registry System: tert-butyl 4-(((6-chloro-4-(trifluoromethyl)pyridine-2-yl)methoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate(1004794-09-5)

Safety Data

• Hazardous Substances Data: 1004794-09-5(Hazardous Substances Data)

Upstream product

• 22123-14-4 2-chloro-6-methyl-4-(trifluoromethyl)pyridine 
• 862120-75-0 2-(bromomethyl)-6-chloro-4-(trifluoromethyl)pyridine 
• 158144-85-5 1-t-butoxycarbonyl-4-phenyl-4-hydroxymethyl piperidine 
• 170291-52-8 tert-butyl 4-(4-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylate 

Downstream Products

• 1416949-06-8 C₂₅H₂₉F₄N₃O 
• 1416949-09-1 C₂₀H₂₂F₄N₂O 
• 1004793-46-7 2-chloro-6-(((4-(4-fluorophenyl)-1-methylpiperidin-4-yl)methoxy)methyl)-4-(trifluoromethyl)pyridine 

Relevant articles and documents

Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression

A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK1/SERT affinity. Optimization based on NK1/SERT binding affinities, and minimization of off-target ion channel activity lead to the

SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.