1416949-06-8Relevant articles and documents
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression
Gillman, Kevin W.,Parker, Michael F.,Silva, Mark,Degnan, Andrew P.,Tora, George O.,Lodge, Nicholas J.,Li, Yu-Wen,Lelas, Snjezana,Taber, Matthew,Krause, Rudolf G.,Bertekap, Robert L.,Newton, Amy E.,Pieschl, Rick L.,Lengyel, Kelly D.,Johnson, Kim A.,Taylor, Sarah J.,Bronson, Joanne J.,MacOr, John E.
, p. 407 - 411 (2013/02/23)
A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK1/SERT affinity. Optimization based on NK1/SERT binding affinities, and minimization of off-target ion channel activity lead to the
