100515-19-3

Basic information

• Product Name: Benzene, 1-(dimethoxymethyl)-4-(methylsulfonyl)-
• CAS NO: 100515-19-3
• Molecular Formula: C10H14O4S
• Molecular Weight: 230.285
• Mol File: 100515-19-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(dimethoxymethyl)-4-(methylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(dimethoxymethyl)-4-(methylsulfonyl)-(100515-19-3)
• EPA Substance Registry System: Benzene, 1-(dimethoxymethyl)-4-(methylsulfonyl)-(100515-19-3)

Safety Data

• Hazardous Substances Data: 100515-19-3(Hazardous Substances Data)

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 67-56-1 methanol 
• 5398-77-6 para-methanesulfonylbenzaldehyde 

Downstream Products

• 5398-77-6 para-methanesulfonylbenzaldehyde 

Relevant articles and documents

Synthesis of 4-sulfur-substituted (2S,3R)-3-phenylserines by enzymatic resolution. Enantionure precursors for thiamphenicol and florfenicol

Enantiomerically pure 4-methylthio- and 4-methylsulfonylsubstitutcd (2S,3R)-3-phenylserines are prepared by enzymatic resolution of the corresponding racemic threo amides using the amidase from Ochrobactrum anthropi NCIMB 40321. The unwanted (2R,3S) enantiomers of the amides are separated from the enantiopure amino acids and easily racemized after Schiff base formation with the corresponding 4-(methylthio)- and 4-(methylsulfonyl)benzaldehyde. The racemization can be combined with the preparation of the racemic amides by aldol reaction under crystallization conditions to yield only the threo isomers. Enantiopure (25,3R)-3-[4-(methylthio)phenyl]serine and (2S,3R)-3-[4-(methylsulfonyl)phenyl]serine are thus obtained in 78% and 62% overall yields starting from the corresponding substituted benzaldehydes. (2S,3A)-3-[4-(Methylthio)phenyl]serine is reduced to (1R,2R)-2-amino-1-[4-(methylthio)phenyl]propane-1,3-diol with NaBH4/H2SO4 and can be used for the synthesis of thiamphenicol and florfenicol.

NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —C(O)—, —O—, —S—, —S(O)—, or —S(0)2— and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

BENZENESULFONAMIDE DERIVATIVE

A novel benzenesulfonamide derivative of formula (I) which has an action of inhibiting phospholipase A2? and therefore is effective in treating diseases for which this action is used to advantage.