100516-98-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Methylthiazole-2-carbonitrile 97 is used as a chemical intermediate for the synthesis of various active pharmaceutical ingredients. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methylthiazole-2-carbonitrile 97 is utilized as an intermediate in the production of pesticide products, contributing to the creation of effective solutions for pest control in agriculture.
Used in Antifungal and Antibacterial Applications:
4-Methylthiazole-2-carbonitrile 97 is used for its potential antifungal and antibacterial properties, making it a valuable component in the development of therapeutic products to combat infections and in agricultural products to protect crops from diseases.
Used in Organic Synthesis:
As a building block in organic synthesis, 4-Methylthiazole-2-carbonitrile 97 is used to create a wide range of chemical compounds for various applications across different industries.

InChI:InChI=1/C5H4N2S/c1-4-3-8-5(2-6)7-4/h3H,1H3

Upstream product

• 760201-86-3 4-methyl-thiazole-2-carboxylic acid amide 
• 13750-68-0 4-methyl-thiazole-2-carbaldehyde 
• 298205-15-9 4-methyl-2-thiazolecarboxaldehyde oxime 

Downstream Products

• 117884-17-0 4-methyl-thiazole-2-carbothioic acid amide 
• 1431558-34-7 C₁₇H₁₃FN₄S₂ 
• 1221430-70-1 (+/-)-2-(4-methyl-thiazol-2-yl)-6-(1-phenyl-ethyl)thieno[2,3-d]pyrimidin-4-ylamine 
• 1221430-99-4 6-(2-chloro-benzyl)-2-(4-methyl-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-ylamine 

Relevant academic research and scientific papers

Potassium channel modulators

Provided are compounds of the formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels.

Selective cyclooxygenase-2 inhibitors: Heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents

A series of heteroaryl modified 1,2-diarylimidazoles has been synthesized and found to be potent and highly selective (1000-9000-fold) inhibitors of the human COX-2.3-Pyridyl derived COX-2 selective inhibitor (25) exhibited excellent activity in acute (carrageenan induced paw edema, ED50 = 5.4 mg/kg) and chronic (adjuvant induced arthritis, ED50 = 0.25 mg/kg) models of inflammation. The relatively long half-life of 25 in rat and dog prompted investigation of the pyridyl and other heteroaromatic systems containing potential metabolic functionalities. A number of substituted pyridyl and thiazole containing compounds (e.g., 44, 46, 54, 76, and 78) demonstrated excellent oral activity in every efficacy model evaluated. Several orally active diarylimidazoles exhibited desirable pharmacokinetics profiles and showed no GI toxicity in the rat up to 100 mg/kg in both acute and chronic models. The paper describes facile and practical syntheses of the targeted diarylimidazoles. The structure-activity relationships and antiinflammatory properties of a series of diarylimidazoles are discussed.