100517-84-8

Upstream product

• 79222-77-8 ethyl 2-[6-phenyl-pyridazin-3(2H)-one-2-yl]-acetate 
• 98-86-2 acetophenone 
• 2166-31-6 6-phenylpyridazin-3(2H)-one 

Downstream Products

• 1456070-60-2 N'-(phenylmethylidene)-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-61-3 N'-[(4-methylphenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-62-4 N'-[(4-chlorophenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-63-5 N'-[(4-methoxyphenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-64-6 N'-[(4-fluorophenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 

Relevant academic research and scientific papers

Synthesis of some new 3(2H)-pyridazinone derivatives and evaluation of their analgesic-anti-inflammatory and antimicrobial activities

In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.