79222-77-8

Upstream product

• 2166-31-6 6-phenylpyridazin-3(2H)-one 
• 105-36-2 ethyl bromoacetate 
• 98-86-2 acetophenone 

Downstream Products

• 91973-93-2 2-[6-phenyl-pyridazin-3(2H)-one-2-yl]-acetic acid 
• 100517-84-8 2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 63900-48-1 2-acetonyl-6-phenyl-3(2H)-pyridazinone 
• 1456070-64-6 N'-[(4-fluorophenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-63-5 N'-[(4-methoxyphenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-62-4 N'-[(4-chlorophenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-61-3 N'-[(4-methylphenyl)methylidene]-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 1456070-60-2 N'-(phenylmethylidene)-2-(6-phenyl-3-oxo-2H-pyridazin-2-yl)acetohydrazide 
• 346407-30-5 N₁-(4-amino-3-methyl-1-propyl-uracil-5-yl)-2-[6-phenyl-pyridazin-3(2H)-one-2-yl]-acetamide 
• 346407-20-3 N₁-(4-amino-1,3-dimethyl-uracil-5-yl)-2-[6-phenyl-pyridazin-3(2H)-one-2-yl]-acetamide 

Relevant academic research and scientific papers

Synthesis of some new 3(2H)-pyridazinone derivatives and evaluation of their analgesic-anti-inflammatory and antimicrobial activities

In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by 1H-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.

Structure-activity relationships in a series of 8-substituted xanthines as A1-adenosine receptor antagonists

A series of 8-substituted xanthines were synthesized and their affinity in vitro towards A1, A2A-adenosine receptors was evaluated by radioligand receptor binding assays. All compounds showed a greater affinity and selectivity toward