100520-55-6Relevant academic research and scientific papers
Synthesis of arylethyl (E)-styrylsulfones and arylsulfones by one-pot DIBAL-H/NaH-mediated reaction of β-ketosulfones
Chang, Meng-Yang,Chen, Yi-Chia,Chan, Chieh-Kai
, p. 1739 - 1744 (2014)
A facile one-pot synthetic route for preparing a series of arylethyl (E)-styrylsulfones or arylethyl arylsulfones is developed. The efficient one-pot DIBAL-H/NaH-mediated route includes reduction of α-benzyl-β- arylketosulfones and retroaldol/aldol or retro aldol reaction of the resulting intermediate. The DIBAL-H/NaH-mediated reaction mechanism has been discussed. Georg Thieme Verlag Stuttgart. New York.
Alkyl alkyl sulfone compound as well as synthesis method and application thereof
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Paragraph 0055-0058, (2020/08/30)
The invention discloses an alkyl alkyl sulfone compound as shown in a formula (1) (See the specification) and a synthesis method of a reagent as shown in a reaction formula (A) (See the specification). Alkyl p-methanesulfonate, an inorganic sulfur reagent and alkyl halide are used as reaction raw materials and react in a solvent under the action of alkali, a reducing agent and an additive to obtain a series of alkyl alkyl sulfone compounds. According to the invention, the alkyl alkyl sulfone compound is constructed in one step by taking an inorganic sulfur reagent as a sulfur dioxide source under a reduction condition, so that the defect of traditional synthesis of an alkyl alkyl sulfone compound through thioether oxidization is avoided; and the alkyl alkyl sulfone compound developed by the invention can successfully realize the connection of complex molecules.
