100546-84-7 Usage
Chemical structure
1,8-Naphthyridine-3-carboxylic acid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, ethyl ester is a complex organic molecule with a naphthyridine core, fluorophenyl and piperazinyl substituents, and an ethyl ester group.
Core structure
The naphthyridine core is a fused ring system consisting of a pyridine and a pyrimidine ring.
Functional groups
The carboxylic acid functional group is present at the 3-position of the naphthyridine core, and the ethyl ester group is attached to the carboxylic acid.
Fluorination
The molecule contains two fluorine atoms, one on the phenyl ring and one on the naphthyridine ring, which can influence the compound's lipophilicity and metabolic stability.
Substituents
The 4-fluorophenyl and 3-methyl-1-piperazinyl substituents are attached to the naphthyridine core, potentially contributing to the compound's biological activity.
Potential pharmaceutical applications
Due to its complex structure and various functional groups, 1,8-Naphthyridine-3-carboxylic acid,
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
, ethyl ester may have a wide range of biological activities and could serve as a lead compound in drug discovery research.
Bioavailability
The presence of the ethyl ester group suggests that the compound may have improved bioavailability, as esters are generally more lipophilic and can more easily cross cell membranes.
Lead compound
As a result of its unique structure and potential biological activities, 1,8-Naphthyridine-3-carboxylic acid,
6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
, ethyl ester could be a valuable starting point for the development of new drugs targeting various diseases or conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 100546-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,5,4 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 100546-84:
(8*1)+(7*0)+(6*0)+(5*5)+(4*4)+(3*6)+(2*8)+(1*4)=87
87 % 10 = 7
So 100546-84-7 is a valid CAS Registry Number.
100546-84-7Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents
Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Claiborne, Akiyo K.,Gracey, Eugene H.,Pernet, Andre G.
, p. 2364 - 2369 (2007/10/02)
Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.
