1005495-75-9Relevant academic research and scientific papers
Enantioselective Synthesis of 2,2,3-Trisubstituted Indolines via Bimetallic Relay Catalysis of α-Diazoketones with Enones
Yang, Jian,Ke, Chaoqi,Zhang, Dong,Liu, Xiaohua,Feng, Xiaoming
, p. 4536 - 4539 (2018/08/07)
An efficient asymmetric intramolecular trapping of ammonium ylides of α-diazoketones with enones to synthesize indoline derivatives was realized. A Rh(II)/chiral N,N′-dioxide-Sc(III) complex bimetallic relay catalytic system was established. A series of optically active 2,2,3-trisubstituted indolines were obtained in high yields (up to 99%), good enantioselectivities (up to 99% ee), and excellent diastereoselectivities (up to >19:1 dr) under mild reaction conditions.
Cross-coupling reactions of aryl halides with amines, phenols, and thiols catalyzed by an N,N′-dioxide-copper(I) catalytic system
Yang, Haitao,Xi, Chao,Miao, Zhiwei,Chen, Ruyu
supporting information; experimental part, p. 3353 - 3360 (2011/08/03)
The coupling reactions of various N, O, and S nucleophilic reagents with aryl halides have been successfully carried out under mild conditions by using a novel chiral N,N′-dioxide-copper(I) catalytic system as the catalyst. This versatile and efficient catalyst system has been demonstrated to facilitate the cross-coupling reactions of aryl halides with amines, phenols, and thiols to afford the corresponding desired products in good to excellent yields.
An N,N′-dioxide/In(OTf)3 catalyst for the asymmetric hetero-Diels-Alder reaction between Danishefsky's dienes and aldehydes: Application in the total synthesis of triketide
Yu, Zhipeng,Liu, Xiaohua,Dong, Zhenhua,Xie, Mingsheng,Feng, Xiaoming
, p. 1308 - 1311 (2008/12/22)
(Chemical Equation Presented) In-teresting catalyst: An asymmetric hetero Diels-Alder reaction between Danishefsky's dienes and various aldehydes using an N,N′-dioxide/In(OTf)3 complex affords highly substituted chiral dihydropyranones with up
Direct allylation of aldimines catalyzed by C2-symmetric N,N′-dioxide-ScIII complexes: Highly enantioselective synthesis of homoallylic amines
Li, Xing,Liu, Xiaohua,Fu, Yingzi,Wang, Lijia,Zhou, Lin,Feng, Xiaoming
supporting information; experimental part, p. 4796 - 4798 (2009/05/07)
A study was conducted for catalytic asymmetric direct allylation of aldimines accelerated by C2-symmetric N,N'-dioxide-ScIII complexes under mild conditions. The study observed that chiral N,N'-dioxidemetal complexes in catalytic asymmetric reactions showed good activation of allylstannane reagent and 2-aminophenol-derived aldimines. It was also observed that the modular and tuneable N,N'-dioxide ligands can be synthesized from readily accessible chiral amino acids and amines, that lead to the catalyst structure optimization. The chiral backbone and steric effects of the amide portion of ligands made a significant impact on the enantioselectivity for this reaction. It was also observed during study that homoallylic amines obtained with high enantioselectivities and good yields under mild conditions.
