943784-90-5

Basic information

• Product Name: (S)-N-(2,6-diisopropyl-phenyl)pyrrolidine-2-carboxamide
• Synonyms: (S)-N-(2,6-diisopropyl-phenyl)pyrrolidine-2-carboxamide
• CAS NO: 943784-90-5
• Molecular Weight: 274.406
• Mol File: 943784-90-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (S)-N-(2,6-diisopropyl-phenyl)pyrrolidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(2,6-diisopropyl-phenyl)pyrrolidine-2-carboxamide(943784-90-5)
• EPA Substance Registry System: (S)-N-(2,6-diisopropyl-phenyl)pyrrolidine-2-carboxamide(943784-90-5)

Safety Data

• Hazardous Substances Data: 943784-90-5(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 3105-95-1 pipecolinic acid 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 24544-04-5 2,6-diisopropylbenzenamine 

Downstream Products

• 1253594-35-2 (S)-2,6-diisopropyl-N-(pyrrolidin-2-ylmethyl)aniline 
• 1281987-84-5 C₂₁H₃₄N₂O₂S 
• 1313735-04-4 C₂₄H₃₂N₂O₂ 
• 1621189-47-6 (7aS,7'aS,E)-2,2'-bis(2,6-diisopropylphenyl)-1,1',2,2',5,5',6,6',7,7',7a,7'a-dodecahydro-3,3'-bipyrrolo[1,2-c]imidazolylidene 
• 1621189-49-8 (S)-2-(2,6-diisopropylphenyl)tetrahydro-1H-pyrrolo[1,2-c]imidazole-3(2H)-thione 
• 1621189-28-3 (S)-2-(2,6-diisopropylphenyl)-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-2-ium hexafluorophosphate 
• 1005495-75-9 C₃₇H₅₆N₄O₂ 

Relevant articles and documents

Chiral bisformamides as effective organocatalysts for the asymmetric one-pot, three-component strecker reaction

(Chemical Equation Presented) C2-symmetric chiral bisformamides have been shown to catalyze the asymmetric one-pot, three-component Strecker reaction, which produced the α-amino nitriles in excellent yields (up to 99%) with good enantioselectiv

Modular synthesis of new bicyclic carbene precursors

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring

Chiral Lewis Base-Catalyzed, Enantioselective Reduction of Unprotected β-Enamino Esters with Trichlorosilane

Catalytic asymmetric reduction of N-unsubstituted β-enamino esters represents a major challenge for asymmetric catalysis. In this paper, the first organocatalytic system that could be used for the asymmetric hydrosilylation of N-unsubstituted β-enamino esters has been developed. Using N-tert-butylsulfinyl-L-proline-derived amides and L-pipecolinic acid-derived formamides as catalyst, a broad range of β-aryl- and β-alkyl-substituted free β-amino esters could be prepared with high yields and enantioselectivities. The practicality was illustrated by the gram-scale asymmetric synthesis of ethyl (R)-3-amino-3-phenylpropanoate and isopropyl (S)-3-amino-4-(2,3,5-trifluorophenyl)butanoate. The resulting product can be smoothly transformed to the FDA approved medicines dapoxetine and sitagliptin in a short synthetic route.