100559-87-3

Upstream product

• 22065-72-1 Cyanessigsaeure-o-nitrophenylester 
• 159851-66-8 2,4-Diphenyl-6-thioxo-6H-1,3-thiazin-5-carbonitril 
• 159851-76-0 α-Cyan-β-(thiobenzamido)thiozimtsaeure-S-ethylester 

Downstream Products

• 159851-94-2 3,4-Dihydro-3-(2-hydroxyethyl)-2,6-diphenyl-4-thioxopyrimidin-5-carbonitril 
• 51735-97-8 α-Cyan-β-(cyclohexylamino)thiozimtsaeure-cyclohexylamid 
• 159851-78-2 3,4-Dihydro-3-(3-hydroxypropyl)-4-oxo-2,6-diphenylpyrimidin-5-carbonitril 
• 159851-66-8 2,4-Diphenyl-6-thioxo-6H-1,3-thiazin-5-carbonitril 
• 159851-77-1 3,4-Dihydro-3-(2-hydroxyethyl)-4-oxo-2,6-diphenylpyrimidin-5-carbonitril 
• 2387-23-7 1,3-Dicyclohexylurea 

Relevant academic research and scientific papers

Synthesis of N-Substituted Oxo- and Thioxopyrimidines from 1,2,4-Dithiazolium Salts

2,4-Diaryl-substituted 1,3-thiazine-5-carbonitriles 5, 6, obtained by reaction of 1,2,4-dithiazolium salts 1 with activated cyanoacetates, undergo ring transformations in the presence of primary and secondary amines.Thus, 5 and 6 react with primary amines under mild conditions to give hardly accessible N-3-substituted oxopyrimidine- or thioxopyrimidine-5-carbonitriles 11, 16, with secondary amines to give N-3-unsubstituted pyrimidine derivatives 14, 19 and with diamines to give imidazopyrimidines or pyrimidopyrimidines 23a, b.After alkylation of 1,3-thiazines 6, highly reactive 1,3-thiazinium salts 8 can be isolated. - Key Words: 1,3-Thiazines / Pyrimidines / Thiazinium salts