737-54-2

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidinecarbonitrile, 1,4-dihydro-4-oxo-2,6-diphenylis used as a chemical precursor for the production of pharmaceutical drugs. Its unique structure and properties make it a valuable component in the synthesis of new and innovative medications.
Used in Organic Synthesis:
As a reagent in organic chemical reactions, 5-Pyrimidinecarbonitrile, 1,4-dihydro-4-oxo-2,6-diphenylis used to facilitate the synthesis of various organic compounds. Its versatility in chemical reactions contributes to the development of a wide range of organic products.
Used in Medicinal Chemistry Research:
5-Pyrimidinecarbonitrile, 1,4-dihydro-4-oxo-2,6-diphenylis used as a subject of study in medicinal chemistry research. Its potential biological activities and therapeutic uses are being explored to develop new drugs and treatments for various medical conditions.
Used in Drug Development:
In the field of drug development, 5-Pyrimidinecarbonitrile, 1,4-dihydro-4-oxo-2,6-diphenylis used as a key component in the creation of new pharmaceutical formulations. Its unique properties and potential applications make it a valuable asset in the development of novel and effective medications.

Upstream product

• 107-91-5 cyanoacetic acid amide 
• 98-88-4 benzoyl chloride 
• 19344-10-6 (Z)-N-(ethoxy(phenyl)methylene)benzamide 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 124-41-4 sodium methylate 
• 2169-69-9 ethyl (E)-2-cyano-3-phenyl-2-propenoate 
• 1670-14-0 benzamidine monohydrochloride 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 100559-87-3 6-Oxo-2,4-diphenyl-6H-1,3-thiazin-5-carbonitril 
• 64502-69-8 3,5-diphenyl-1,2,4-dithiazol-1-ium perchlorate 
• 68364-41-0 5-Cyano-4-methylthio-2,6-diphenylpyrimidine 
• 14533-94-9 Z-Methyl 2-Cyano-3-methoxy-3-phenylpropenoate 
• 875327-56-3 [2-(2,6-Diphenyl-3,4-dihydro-5-cyan-4-oxo-pyrimidin-3-yl)-ethylthio]-essigsaeure 
• 875327-48-3 2,6-Diphenyl-3,4-dihydro-3-(2-chlorethyl)-4-oxo-pyrimidin-5-carbonitril 

Downstream Products

• 741-90-2 4-ethoxy-2,6-diphenylpyrimidine-5-carbonitrile 
• 67677-96-7 4-anilino-2,6-diphenyl-pyrimidine-5-carbonitrile 
• 739-77-5 4-hydrazino-2,6-diphenyl-pyrimidine-5-carbonitrile 
• 122379-76-4 5-cyano-2,4-diphenyl-6-(o-carboxyphenylamino)pyrimidine 
• 122379-77-5 4-cyano-1,3-diphenyl-10H-pyrimido<6,1-b>quinazolin-10-one 
• 122379-71-9 8-cyano-2,3-dihydro-5,7-diphenyl-1,2,4-triazolo<4,3-c>pyrimidine-3-thione 
• 122379-73-1 8-cyano-5,7-diphenyltetrazolo<4,5-c>pyrimidine 
• 737-53-1 4-chloro-2,6-diphenylpyrimidine-5-carbonyltrile 

Relevant academic research and scientific papers

Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase

Here we report the first small-molecule inhibitors of human sulfide:quinone oxidoreductase (SQOR) that decrease the rate of breakdown of hydrogen sulfide (H2S), a potent cardioprotective signaling molecule. SQOR is a mitochondrial membrane-boun

COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE

The present invention relates to the discovery of novel compounds that can be used to treat and/or prevent heart failure in a subject. In certain embodiments, the compounds of the invention are sulfide: quinone oxidoreductase (SQOR) inhibitors. In other e

HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING SAME

The present specification relates to a hetero-cyclic compound and an organic light emitting device comprising the same.

ELECTROACTIVE MATERIALS

There is disclosed a compound which is an N-heterocycle having at least one substituent of Formula (I), In Formula I: Q1, Q2, Q3, Q4, and Q5 are the same or different and can be N or CR1; R1 is the same or different at each occurrenc

MULTICYCLIC COMPOUND INCLUDING NITROGEN AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

Provided are a polycyclic compound including nitrogen, represented by chemical formula 1 and an organic light emitting device using the same. According to an embodiment of the present invention, the compound can improve efficiency of an organic light emit

Rapid three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of Bi(NO3)3·5H2O as a mild and highly efficient catalyst

Bismuth(III) nitrate pentahydrate is found as a mild and highly efficient catalyst for the rapid synthesis of 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives via three-component reaction of aldehydes, N-unsubstituted amidines, and malononit

Antinociceptive pyrimidine derivatives: Aqueous multicomponent microwave assisted synthesis

Pyrimidines and their oxo-derivatives are well researched due to their anti-inflammatory, analgesic, antimicrobial, antiviral, and interferon inducing activities. New pyrimidine derivatives are therefore frequently synthesized to build up small molecule libraries for the discovery of drug candidates. Synthesis of 2,6-diaryl-4-(3H)-pyrimidinones and 2,6-diaryl-4-aminopyrimidines is traditionally a 2-day laboratory effort carried out in two steps, always using ethanol as solvent, and triethylamine as base. In this Letter, we advance a one-step alternative synthetic method with a 40 min reaction time using a microwave reactor in an aqueous media with potassium carbonate as base. The average yields were also somewhat improved. This new method thus emerges as more eco-friendly, not only because it does not employ triethylamine as base, but also due to a much reduced usage of organic solvents, leading to less harmful residues. Using this method, we synthesized twenty pyrimidine derivatives with antinociceptive activities in satisfactory chemical yields.

Three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of high-surface-area MgO, a highly effective heterogeneous base catalyst

Magnesium oxide (MgO) effectively catalyzes the three-component reaction of aldehydes, amidine systems, and malononitrile or ethyl cyanoacetate to form 4-amino-5-pyrimidine carbonitrile and pyrimidinone derivatives, respectively. The salient features of t

Protected mercaptoalkylpyrimidinones: Synthesis and test for immunostimulating activity

3-Hydroxyalkyl-pyrimidine 1 reacts with phosphoroxychloride and thioglycolic acid or thiourea to yield pyrimidin-3-ylalkylthioacetic acids 3 or pyrimidin-3-ylalkylthiouroniumsalts 5 respectively. Some of the pyrimidines 3 and 5 showed immunomodulatory activity.

Regioselective Synthesis of Pyrimidines from Ketene Dithioacetals or Alkoxymethylene Compounds

Regioselective cyclizations of the condensation products obtained by the reaction of nitrogen nucleophiles with ketene dithioacetals or alkoxymethylene compounds are reported.Stereoelectronic factors or geometry of the carbon-carbon double bond determine