2039-06-7Relevant academic research and scientific papers
C-(β-d-Glucopyranosyl)formamidrazones, formic acid hydrazides and their transformations into 3-(β-d-glucopyranosyl)-5-substituted-1,2,4- triazoles: A synthetic and computational study
Bokor, éva,Fekete, Attila,Varga, Gergely,Szocs, Béla,Czifrák, Katalin,Komáromi, István,Somsák, László
, p. 10391 - 10404 (2013)
Synthesis of O-perbenzoylated 3-(β-d-glucopyranosyl)-5-substituted-1, 2,4-triazoles, precursors of potent inhibitors of glycogen phosphorylase, was studied by ring closures of N1-acyl-carboxamidrazone type intermediates. Reactions of C-(β-d-glu
PEG-supported synthesis of 3,5-disubstituted 1,2,4-triazoles
Wang, Jun-Ke,Zong, Ying-Xiao,Yue, Guo-Ren
, p. 1135 - 1136 (2005)
1,3-Dipolar cycloadditions between diethyl azodicarboxylate and the polymer-bound munchnones generated from the corresponding carboxylic acids provided a library of 3,5-disubstituted 1,2,4-triazoles in excellent yield and high purity.
The Synthesis of 1,3,5-Thiadiazinylium Salts
Shibuya, Isao
, p. 3369 - 3370 (1980)
1,3,5-Thiadiazinylium salts were synthesized in good yields by the reaction of N-acyl imidoyl chlorides with thioamides or the treatment of 4H-1,3,5-thiadiazines with trityl salts.
Liquid-phase traceless synthesis of 3,5-disubstituted 1,2,4-triazoles
Wang, Xi-Cun,Wang, Jun-Ke,Wu, Dong-Qing,Zong, Ying-Xiao
, p. 2595 - 2598 (2005)
A liquid-phase traceless route to 3,5-disubstituted-1,2,4-triazoles has been developed, which allows for the incorporation of two elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxy-benzaldehyde, from which a traceless cleavage could be realized with TFA-CH2Cl2. This method provided a library of 3,5-disubstituted-1,2,4-triazoles with high yields and purity. Georg Thieme Verlag Stuttgart.
Solid phase synthesis of 1,2,4-triazoles under microwave irradiation
Rostamizadeh, Shahnaz,Tajik, Hasan,Yazdanfarahi, Soheila
, p. 113 - 117 (2003)
1,2,4-Triazoles (3a-g) have been prepared from three component condensation reaction of acid hydrazide (1), S-methyl isothioamide hydroiodide (2), and ammonium acetate on the surface of silica gel under microwave irradiation.
1,2,4-Triazolato paddlewheel dibismuth complexes with very short Bi(ii)-Bi(ii) bonds: Bismuth(iii) oxidation of 1,2,4-triazolato anions into neutral: N -1,2,4-triazolyl radicals
He, Ru-Ru,Li, Li,Ma, Jian-Ping,Su, Ji-Hu,Zhang, Xiang,Zhao, Ming-Gang,Zheng, Wenjun
, p. 15190 - 15194 (2020)
Bismuth(iii) oxidation of 3,5-di-substituted-1,2,4-triazolato anions afforded a paddlewheel 1,2,4-triazolato dibismuth complex [L2(Bi-Bi)L2] (L = η1,η1-3,5-R2tz, R = Ph (3), iPr (4)) with very short Bi(ii)-Bi(ii) bonds (2.8650(4)-2.8721(3) ?). The reaction involved the intermediates of the organobismuth radical [Bi(R2tz)2] and neutral N-1,2,4-triazolyl radical [3,5-R2tz]. The dimerization of the former produced the corresponding dibismuth complex while the latter was trapped by using spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) to give the radical adduct of {(3,5-R2tz)(DMPO)} which was unambiguously evidenced by EPR analysis.
A base-catalyzed, direct synthesis of 3,5-disubstituted 1,2,4-triazoles from nitriles and hydrazides
Yeung, Kap-Sun,Farkas, Michelle E.,Kadow, John F.,Meanwell, Nicholas A.
, p. 3429 - 3432 (2005)
A convenient and efficient one step, base-catalyzed synthesis of 3,5-disubstituted 1,2,4-triazoles by the condensation of a nitrile and a hydrazide is presented. A diverse range of functionality and heterocycles are tolerated under the reaction conditions
Iodine Catalyzed Oxidative Coupling of Diaminoazines and Amines for the Synthesis of 3,5-Disubstituted-1,2,4-Triazoles
Beifuss, Uwe,Bharatam, Prasad V.,Chourasiya, Sumit S.,Kathuria, Deepika,Sahoo, Subash C.,Wani, Aabid A.
, p. 7659 - 7671 (2021/06/25)
A simple, convenient, transition metal-free one pot synthesis of 3,5-disubstituted-1,2,4-triazoles has been established. The innovation in this reaction is the use of easily available 1,1-diaminoazines as substrates. This method provides the products with wider substrate scope, at an expedited rate, and with relatively better yields in comparison to the reported methods. The reaction mechanism involves an initial intermolecular nucleophilic addition (facilitated by I2) followed by intramolecular nucleophilic cyclization.
A practical base mediated synthesis of 1,2,4-triazoles enabled by a deamination annulation strategy
Zhang, Chunyan,Liang, Zuyu,Jia, Xiaofei,Wang, Maorong,Zhang, Guoying,Hu, Mao-Lin
supporting information, p. 14215 - 14218 (2020/11/24)
A rapid and efficient base mediated synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed using the annulation of nitriles with hydrazines, which can be expanded to a wide range of triazoles in good to excellent yields. Ammonia gas is liberated during the reaction, and halo and hetero functional groups as well as free hydroxyl and amino groups are tolerated in this transformation. A variety of alkyl and aryl-substituted nitriles can be functionalized with aromatic and aliphatic hydrazines employing this procedure. This finding provides a practical and useful strategy for the synthesis of various 15N-labeled 1,2,4-triazole derivatives, and two types of mGlu5 receptor pharmaceuticals can be easily assembled in a one-pot manner. This journal is
Green aqueous synthesis and antimicrobial evaluation of 3,5-disubstituted 1,2,4-triazoles
Beyzaei, Hamid,Malekraisi, Farideh,Aryan, Reza,Ghasemi, Behzad
, p. 482 - 487 (2020/05/25)
[Figure not available: see fulltext.] An eco-friendly and simple procedure was proposed for the synthesis of 3,5-disubstituted 1,2,4-triazoles by optimized reaction of benzamidine hydrochloride and various aryl hydrazides. H2O and K2
