1005786-00-4

Basic information

• Product Name: 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid
• Synonyms: 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid;4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid(WXC03681)
• CAS NO: 1005786-00-4
• Molecular Formula: C₁₇H₂₈O₃Si
• Molecular Weight: 308.48792
• Mol File: 1005786-00-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid(1005786-00-4)
• EPA Substance Registry System: 4-(1-((Tert-Butyldimethylsilyl)Oxy)-2-Methylpropan-2-Yl)Benzoic Acid(1005786-00-4)

Safety Data

• Hazardous Substances Data: 1005786-00-4(Hazardous Substances Data)

Usage

Uses

4-[1-[tert-Butyl(dimethyl)silyl]oxy-2-methylpropan-2-yl]benzoic Acid is used as a reactant in the preparation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 
• 1005785-96-5 ethyl 4-(1-hydroxy-2-methylpropan-2-yl)benzoate 
• 1005785-98-7 ethyl 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoate 

Downstream Products

• 1005786-60-6 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)benzamide 
• 1005786-63-9 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide 
• 1189852-20-7 4-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1189853-38-0 4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1189852-68-3 4-(1-hydroxy-2-methylpropan-2-yl)-N-(2-methyl-7-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzamide 
• 1189852-71-8 4-tert-butyl-N-[7-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-5-yl]benzamide 
• 1189852-21-8 N-(7-chloro-2-methylpyrazolo[1,5-a]pyrimidin-5-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzamide 
• 1202053-82-4 N-(5-bromothiazolo[5,4-b]pyridin-2-yl)-4-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)benzamide 
• 1005786-45-7 4-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)benzoyl chloride 

Relevant articles and documents

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

Imidazo[1,2-a]pyridine derivatives were designed, synthesized, and evaluated as inhibitors of the apoptosis signal-regulating kinase 1 (ASK1). These were based on a benzothiazole derivative that was discovered from high-throughput screening of our compound library. As a result, we identified potent, selective, and orally bioavailable ASK1 inhibitors for wide range of therapeutic targets.

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS

The present invention relates to apoptosis signal-regulating kinase 1 (“ASK1”) inhibiting compounds of the formula wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture com