95383-36-1

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-4-FLUOROBENZOYL CHLORIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-4-FLUOROBENZOYL CHLORIDE serves as a precursor for the production of various agrochemicals, including pesticides and herbicides. Its reactivity and structural features contribute to the creation of effective compounds for agricultural applications.
Used in Organic Synthesis:
2-BROMO-4-FLUOROBENZOYL CHLORIDE is utilized as a versatile reagent in organic chemistry for the preparation of a wide range of compounds, such as benzoyl fluorides, ketones, and esters. Its high reactivity enables the formation of diverse chemical products for various applications.

InChI:InChI=1/C7H3BrClFO/c8-6-3-4(10)1-2-5(6)7(9)11/h1-3H

Upstream product

• 79-37-8 oxalyl dichloride 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 1254073-58-9 4-[(3-chloro-4-fluoro-2-methylphenyl)carbonyl]-2-piperazinone 

Downstream Products

• 220603-06-5 [2-bromo-4-fluorophenyl]-(6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)-methanone 
• 924660-36-6 N-benzyl-2-bromo-4-fluorobenzamide 
• 1185755-97-8 C₁₄H₁₂BrFN₂O₃S 
• 1093868-91-7 2-(2-bromo-4-fluorophenyl)-4,4-dimethyl-2-oxazoline 
• 1016855-70-1 2-bromo-N-cyclohexyl-4-fluoro-N-methylbenzamide 
• 1273122-95-4 C₁₇H₁₂BrFN₂O₃ 
• 1376129-52-0 2-benzyl-5-fluoro-2,3-dihydro-1H-inden-1-one 
• 13294-42-3 (2-bromo-4-fluorophenyl)(phenyl)methanone 
• 923138-87-8 C₈H₇BrFNO 
• 935657-73-1 2-bromo-4-fluorobenzoic acid hydrazide 

Relevant academic research and scientific papers

PREPARATION METHOD FOR DEUTERATED MACROCYCLIC COMPOUND

Provided are a compound as represented by formula (D) and a preparation method therefor, where X2 is a halogen, Pg is selected from H and an amino protecting group, such as Cbz, Boc, Fmoc, Alloc, Teoc, methoxycarbonyl or ethoxycarbonyl. Also pr

Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives

[Figure not available: see fulltext.] Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for 3-(tert-butylimino)-5-chloro-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one and serious nervous curl effect against pinewood nematodes B. xylophilus for 3-(tert-butylimino)-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one were observed at 10 mg/l. The inhibition activities of 3-[(4-methoxyphenyl)imino]-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in vitro test and test tube test, respectively.

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Ni-Catalyzed Reductive Arylcyanation of Alkenes

We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features high functional group tolerance. In addition, an enantioselective version was developed for the construction of enantiomerically enriched 3-cyanomethyl oxindole. This method has also been applied to the synthesis of natural alkaloids (+)-esermethole and (+)-physostigmine.

MOLLUGIN DERIVATIVES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE COMPRISING THE SAME

The present invention relates to a pharmaceutical composition for treating inflammatory bowel diseases, comprising mollugin or a mollugin derivative applicable as a therapeutic agent for inflammatory bowel diseases, as an effective component. More specifi

Palladium-Catalyzed Stereoselective Aza-Wacker-Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles

Palladium-catalyzed intramolecular tandem cyclization reactions were conducted for the synthesis of densely cis/cis-fused aza-tetracyclic structures. The process involved a palladium(II)-catalyzed aerobic aza-Wacker reaction, followed by a palladium(0)-catalyzed Heck reaction. The effects of the solvent and benzene substitution pattern on the one-pot, two-step cascade reaction were studied systematically, and a probable mechanism was proposed. Strained pentahydrobenzo[f]cyclopenta[hi]indolizin-6-one and racemic γ-lycorane can also be synthesized rapidly using this palladium-catalyzed aza-Wacker-Heck cyclization reaction.

Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones

The bisphosphine monoxide (R,R)-BozPhos enables enantioselective C-H functionalization of cyclopropanes in a palladium-catalyzed cyclization. The synthesis of a broad spectrum of dihydroisoquinolones and dihydroquinolones in good yields and high enantiomeric excess was achieved through the use of this hemilabile ligand. Furthermore, the isolation of an intermediary palladium(II)-BozPhos complex after oxidative addition was successful and a second complex provided further insight into bond length and angles through a crystal structure.

MOLLUGIN DERIVATIVES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE COMPRISING THE SAME

The present invention relates to a pharmaceutical composition for treating inflammatory bowel disease, comprising mollugin or a mollugin derivative which can be beneficially used as a therapeutic agent for inflammatory bowel disease. More specifically, th

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.

CF3-substituted mollugin 2-(4-morpholinyl)-ethyl ester as a potential anti-inflammatory agent with improved aqueous solubility and metabolic stability

Although mollugin, the main ingredient of the oriental medicinal herb Rubia cordifolia, has considerable anti-inflammatory effects, it has poor aqueous solubility as well as poor metabolic and plasma stability. To overcome these shortfalls, various mollug