1006-93-5

Upstream product

• 1696-17-9 N,N-diethylbenzamide 
• 614-17-5 N-ethylbenzamide 
• 7719-09-7 thionyl chloride 
• 98-88-4 benzoyl chloride 

Downstream Products

• 74180-10-2 N-(2,4-Dinitro)phenyl-N'-ethyl-N-methylbenzamidine 
• 109690-41-7 3-ethyl-5,6-dimethyl-2-phenyl-3H-pyrimidin-4-one 
• 100957-51-5 3,5-diethyl-6-methyl-2-phenyl-3H-pyrimidin-4-one 
• 1775-59-3 N-ethyl-benzimidic acid ethyl ester 
• 825-60-5 benzimidic acid ethyl ester 
• 614-17-5 N-ethylbenzamide 
• 47455-14-1 N-[4-(2-Diethylamino-ethoxy)-phenyl]-N'-ethyl-benzamidine 
• 3472-77-3 1,1,3,4,4,4-Hexachlor-1-phenyl-2-aza-buten-⁽²⁾ 
• 69909-95-1 N-ethyl-N'-(phenyl-thiocarbamoyl)-benzamidine 
• 36640-71-8 1-(N-ethyl-benzimidoyl)-3,5-dimethyl-1H-pyrazole 
• 127040-91-9 4-(N-Ethyl-benzimidoyloxy)-2-methylene-butyric acid methyl ester 
• 127040-93-1 5-(N-Ethyl-benzimidoyloxy)-2-methylene-pentanoic acid methyl ester 
• 36640-70-7 1-(N-ethylbenzimidoyl)-3-carbomethoxy-5-methylpyrazole 
• 36529-78-9 N'-ethyl-N,N-dimethyl-benzamidine 

Relevant academic research and scientific papers

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

Solvent/oxidant-switchable synthesis of multisubstituted quinazolines and benzimidazoles via metal-free selective oxidative annulation of arylamidines

A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp3)-C(sp2) and C(sp 2)-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp3C-H/sp2C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.

Preparation of 1,5-disubstituted tetrazoles under phase-transfer conditions

Imidoyl chlorides, obtained by common methods from a wide range of aromatic mono- and diamides, are smoothly converted to the corresponding tetrazoles in high yields by treatment with NaN3 under phase-transfer conditions.