1006037-10-0Relevant articles and documents
HETEROBICYCLIC COMPOUNDS AS EP4 ANTAGONISTS
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Paragraph 082, (2019/08/26)
The present invention relates to novel EP4 receptor antagonist compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, which can be useful for treating cancer or inflammatory diseases.
Scalable synthesis of a prostaglandin EP4 receptor antagonist
Gauvreau, Danny,Dolman, Sarah J.,Hughes, Greg,Oshea, Paul D.,Davies, Ian W.
supporting information; experimental part, p. 4078 - 4085 (2010/08/22)
The evolution of scalable, economically viable synthetic approaches to the potent and selective prostaglandin EP4 antagonist 1 is presented. The chromatography-free synthesis of multikilogram quantities of 1 using a seven-step sequence (six in the longest
PROCESS FOR MAKING THIOPHENE CARBOXAMIDE DERIVATIVE
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Page/Page column 25-27, (2009/04/25)
The invention encompasses a process for making a thiophene carboxamide derivative, which is an EP4 antagonist useful for treating pain and inflammation.
THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS
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Page/Page column 83-84, (2008/06/13)
The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoi