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1006037-11-1

Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester

    Cas No: 1006037-11-1

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  • 1006037-11-1 Structure

  • Basic information

    1. Product Name: Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester
    2. Synonyms: Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester;JCKNHRNZLPAOQK-UHFFFAOYSA-N
    3. CAS NO:1006037-11-1
    4. Molecular Formula: C26H24F3NO3S
    5. Molecular Weight: 487.5338696
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1006037-11-1.mol

  • Chemical Properties

    1. Melting Point: 220.9-221.7 °C
    2. Boiling Point: 549.9±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.33±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 14.07±0.20(Predicted)
    10. CAS DataBase Reference: Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester(CAS DataBase Reference)
    11. NIST Chemistry Reference: Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester(1006037-11-1)
    12. EPA Substance Registry System: Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester(1006037-11-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1006037-11-1(Hazardous Substances Data)

1006037-11-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1006037-11-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,6,0,3 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1006037-11:
(9*1)+(8*0)+(7*0)+(6*6)+(5*0)+(4*3)+(3*7)+(2*1)+(1*1)=81
81 % 10 = 1
So 1006037-11-1 is a valid CAS Registry Number.

1006037-11-1Relevant articles and documents

Scalable synthesis of a prostaglandin EP4 receptor antagonist

Gauvreau, Danny,Dolman, Sarah J.,Hughes, Greg,Oshea, Paul D.,Davies, Ian W.

supporting information; experimental part, p. 4078 - 4085 (2010/08/22)

The evolution of scalable, economically viable synthetic approaches to the potent and selective prostaglandin EP4 antagonist 1 is presented. The chromatography-free synthesis of multikilogram quantities of 1 using a seven-step sequence (six in the longest

The discovery of 4-{l-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]- 3thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin e2 subtype 4 receptor antagonist

Blouin, Marc,Han, Yongxin,Burch, Jason,Farand, Julie,Mellon, Christophe,Gaudreault, Mireille,Wrona, Mark,Lévesque, Jean-Fran?ois,Denis, Danielle,Mathieu, Marie-Claude,Stocco, Rino,Vigneault, Erika,Therien, Alex,Clark, Patsy,Rowland, Steve,Xu, Daigen,o'Neill, Gary,Ducharme, Yves,Friesen, Rick

experimental part, p. 2227 - 2238 (2010/08/21)

The discovery of highly potent and selective second generation EP4 antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

PROCESS FOR MAKING THIOPHENE CARBOXAMIDE DERIVATIVE

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Page/Page column 25; 27, (2009/04/25)

The invention encompasses a process for making a thiophene carboxamide derivative, which is an EP4 antagonist useful for treating pain and inflammation.

THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS

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Page/Page column 84, (2008/06/13)

The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoi

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