100606-37-9Relevant academic research and scientific papers
Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
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Page 36-37, (2010/02/07)
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
Synthesis of Substituted 1,2-Dihydroisoquinolines by the Intramolecular 1,3-Dipolar Alkyl Azide-Olefin Cycloaddition
Liu, Jia-Ming,Young, Jenn-Jong,Li, Yu-Jang,Sha, Chin-Kang
, p. 1120 - 1123 (2007/10/02)
A general synthesis of substituted 1,2-dihydroisoquinolines based on intramolecular 1,3-dipolar cycloaddition of alkyl azides and olefins is described.Reaction of bromide 4 with sodium azide afforded azide 5, which underwent 1,3-dipolar cycloaddition intramolecularly to give triazoline 6 .Rearrangement of triazoline 6 on silica gel gave diazo compound 7.Treatment of 7 with rhodium acetate afforded substituted 1,2-dihydroisoquinoline 9 in good overall yield.
