100621-53-2

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 6134-57-2 pentane-2,3,4-trione 3-phenylhydrazone 
• 123-54-6 acetylacetone 
• 62-53-3 aniline 
• 100-34-5 benzene diazonium chloride 

Downstream Products

• 147675-01-2 2-Chloro-4,6-dimethyl-5-phenylazo-nicotinonitrile 
• 161388-50-7 Acetic acid (2R,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(3-cyano-4,6-dimethyl-5-phenylazo-2-thioxo-2H-pyridin-1-yl)-tetrahydro-pyran-3-yl ester 
• 161388-70-1 Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(3-cyano-4,6-dimethyl-5-phenylazo-2-thioxo-2H-pyridin-1-yl)-tetrahydro-pyran-3-yl ester 
• 160596-79-2 2-Cyanomethylsulfanyl-4,6-dimethyl-5-phenylazo-nicotinonitrile 
• 160596-80-5 (3-Cyano-4,6-dimethyl-5-phenylazo-pyridin-2-ylsulfanyl)-acetic acid ethyl ester 
• 160596-87-2 3-Amino-4,6-dimethyl-5-phenylazo-thieno[2,3-b]pyridine-2-carbonitrile 
• 160596-81-6 2-(3-Cyano-4,6-dimethyl-5-phenylazo-pyridin-2-ylsulfanyl)-acetamide 
• 160596-85-0 N-(4-Chloro-phenyl)-2-(3-cyano-4,6-dimethyl-5-phenylazo-pyridin-2-ylsulfanyl)-acetamide 
• 160596-83-8 2-(3-Cyano-4,6-dimethyl-5-phenylazo-pyridin-2-ylsulfanyl)-N-p-tolyl-acetamide 
• 160596-86-1 N-(4-Acetyl-phenyl)-2-(3-cyano-4,6-dimethyl-5-phenylazo-pyridin-2-ylsulfanyl)-acetamide 

Relevant academic research and scientific papers

SYNTHESIS OF SOME PHENYLAZOPYRIDOTHIENOPYRIMIDINES

2-Mercapto-5-phenylazo-4,6-dimethylpyridine-3-carbonitrile (3) reacts with halocompounds to give S-alkylated derivatives (4a-h) which upon treatment with sod. ethoxide in ethanol, the thienopyridines (5a-h) was obtained.Compound (5) converted into pyridothienopyrimidines (6a-e) or (7a,b) boiling with triethyl orthoformate or acetic anhydride.Also it can be converted into pyridothienotriazine (8a-d) by treating with nitrous acid.Chloropyridothienopyrimidine (10a,b) was obtained by refluxing compound 6a or 7a with POCl3.Key words: Synthesis, reactions, thienopyridine, pyridothienopyrimidine, pyridothienotriazine.

Reaction of (cyano)thioacetamide with arylhydrazones of β-diketones: Novel synthesis of 2(1H)-pyridinethiones, thieno[2,3-b]pyridines, and pyrazolo[3,4-b]pyridines

A novel synthesis of 2(1H)-pyridinethiones, thieno[2,3-b]pyridines and pyrazolo[3,4-b]pyridines utilizing (cy-ano)thioacetamide and arylhydrazones of 1,3-diketones as starting components is described.