1006300-11-3Relevant academic research and scientific papers
N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Mitchell, Michael L.,Son, Jong Chan,Lee, Ill Young,Lee, Chong-Kyo,Kim, Hae Soo,Guo, Hongyan,Wang, Jianhong,Hayes, Jaclyn,Wang, Michael,Paul, Amber,Lansdon, Eric B.,Chen, James M.,Eisenberg, Gene,Geleziunas, Romas,Xu, Lianhong,Kim, Choung U.
, p. 1585 - 1588 (2010)
A series of N1-heterocyclic pyrimidinediones were extensively evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Inhibitor 1 is active against NNRTI-resistant viruses including RT mutant K103N. The co-crystal structure of inhibit
Novel HIV reverse transcriptase inhibitors
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Page/Page column 37-38, (2008/06/13)
The invention is related to compounds of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
