131747-60-9

Basic information

• Product Name: 2-FLUORO-4-PYRIDINEMETHANOL
• Synonyms: 2-FLUORO-4-PYRIDINEMETHANOL;4-Pyridinemethanol,2-fluoro-(9CI);2-Fluoro-4-pyridinemethanol ,96%;(2-Fluoropyridin-4-yl)methanol;4-PyridineMethanol, 2-fluoro-
• CAS NO: 131747-60-9
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.12
• Product Categories: PYRIDINE
• Mol File: 131747-60-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 247.4 °C at 760 mmHg
• Flash Point: 103.5 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 0.0136mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2-FLUORO-4-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-PYRIDINEMETHANOL(131747-60-9)
• EPA Substance Registry System: 2-FLUORO-4-PYRIDINEMETHANOL(131747-60-9)

Safety Data

• Hazard Codes: F
• Statements: 10-36/37/38-20/21/22
• Safety Statements: 16-26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 131747-60-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow low melting solid

InChI:InChI=1/C6H6FNO/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2

Upstream product

• 402-65-3 2-fluoropyridine-4-carboxylic acid 
• 123412-95-3 ethyl 2-fluoroisonicotinate 
• 541-41-3 chloroformic acid ethyl ester 
• 461-87-0 2-fluoro-4-methylpyridine 
• 1006300-11-3 Benzoic acid 2-fluoro-pyridin-4-ylmethyl ester 
• 155705-46-7 2-fluoro-pyridin-4-ylmethyl chloride 
• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 131747-69-8 2-fluoropyridin-4-carboxyaldehyde 
• 1029689-75-5 (2-methoxypyridin-4-yl)methanamine hydrochloride 
• 777056-79-8 1-(2-fluoropyridin-4-yl)methanamine 
• 1403988-43-1 4-{4-fluoro-2-[(2-fluoropyridin-4-yl)methoxy]phenyl}-N-{3-[(methylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine 
• 84940-51-2 4-(difluoromethyl)-2-fluoropyridine 
• 1224714-80-0 N-(1-{7-[(4-ethoxyphenoxy)methyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)acetamide 
• 1224716-92-0 N-[2-(2-{4-[(4-ethoxyphenoxy)methyl]pyridin-2-yl}hydrazino)-1-methyl-2-oxoethyl]acetamide 
• 1224716-91-9 4-[(4-ethoxyphenoxy)methyl]-2-hydrazinopyridine 
• 1224716-90-8 4-[(4-ethoxyphenoxy)methyl]-2-fluoropyridine 
• 1126776-77-9 4-{1-[(2-fluoropyridin-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}benzonitrile 
• 108338-11-0 2,6-Dimethyl-4-(2-fluoro-4-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 160588-45-4 DMP 543 
• 215674-15-0 2-fluoro-4-(iodomethyl)-pyridine 
• 478962-94-6 C₅₃H₅₁FN₆O₁₁ 

Relevant articles and documents

Oxidation of methyl heteroaryls with molecular oxygen: A facile synthesis of 2-[N-(tert-butoxycarbonyl)amino]-4-pyridinecarbaldehyde

Oxidation of nitrogen-based methyl heteroaryls with molecular oxygen resulted in the formation of the corresponding benzyl alcohols. While experimentally easy and amenable to large-scale preparations, this approach has limitations with respect to the particular nature of heterocyclic substrates. Using this methodology, the title compound, 2-[N-(tert-butoxycarbonyl)amino]-4- pyridinecarbaldehyde, considered to be a versatile pharmaceutical intermediate, was prepared on a multigram scale. Georg Thieme Verlag Stuttgart.

N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

A series of N1-heterocyclic pyrimidinediones were extensively evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Inhibitor 1 is active against NNRTI-resistant viruses including RT mutant K103N. The co-crystal structure of inhibit

Novel HIV reverse transcriptase inhibitors

The invention is related to compounds of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.