863029-84-9Relevant academic research and scientific papers
A Multicatalytic Approach to the Hydroaminomethylation of α-Olefins
Hanna, Steven,Holder, Jeffrey C.,Hartwig, John F.
supporting information, p. 3368 - 3372 (2019/02/24)
We report an approach to conducting the hydroaminomethylation of diverse α-olefins with a wide range of alkyl, aryl, and heteroarylamines at relatively low temperatures (70–80 °C) and pressures (1.0–3.4 bar) of synthesis gas. This approach is based on sim
Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation
Briggs, John R.,Klosin, Jerzy,Whiteker, Gregory T.
, p. 4795 - 4798 (2007/10/03)
(Chemical Equation Presented) We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.
HYDROAMINOMETHYLATION OF OLEFINS
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Page/Page column 18, (2010/02/13)
The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.
