1006391-79-2Relevant academic research and scientific papers
Investigation of the antimycobacterial activity of 8-hydroxyquinolines
Cieslik, Wioleta,Spaczynska, Ewelina,Malarz, Katarzyna,Tabak, Dominik,Nevin, Eoghan,O'Mahony, Jim,Coffey, Aidan,Mrozek-Wilczkiewicz, Anna,Jampilek, Josef,Musiol, Robert
, p. 771 - 779 (2015/12/01)
A series of styrylquinolines and quinolineamides based on the 8-hydroxyquinoline moiety were investigated as potential antimycobacterial agents. The lipophilicity of the compounds was measured using RP-HPLC and the tests of their activity against Mycobacterium kansasii, the M. avium complex, M. smegmatis, M. abscessus, M. tuberculosis and M. avium paratuberculosis was performed. Several of the compounds that were obtained appeared to be more effective than isoniazid and ciprofloxacin. The 5,7-dinitro-8-hydroxyquinoline derivative possessed the highest potency against M. abscessus and M. Smegmatis, which was about twice as effective as ciprofloxacin, while 2-(2-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid appeared to be comparable with the standard drugs that are against the M. avium complex. The structure activity relationships are discussed.
Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity
Musiol, Robert,Tabak, Dominik,Niedbala, Halina,Podeszwa, Barbara,Jampilek, Josef,Kralova, Katarina,Dohnal, Jiri,Finster, Jacek,Mencel, Agnieszka,Polanski, Jaroslaw
, p. 4490 - 4499 (2008/12/20)
Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The com
