23051-08-3

Basic information

• Product Name: 8-hydroxy-2-methylquinoline-7-carboxylic acid
• Synonyms: 8-hydroxy-2-methylquinoline-7-carboxylic acid;2-Methyl-8-Hydroxyquinoline-7-carboxylic acid;8-Hydroxy-2-methyl-7-quinolinecarboxylic acid
• CAS NO: 23051-08-3
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203
• Mol File: 23051-08-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 376.4°C at 760 mmHg
• Flash Point: 181.5°C
• Appearance: /
• Density: 1.410±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 2.46E-06mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 8-hydroxy-2-methylquinoline-7-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydroxy-2-methylquinoline-7-carboxylic acid(23051-08-3)
• EPA Substance Registry System: 8-hydroxy-2-methylquinoline-7-carboxylic acid(23051-08-3)

Safety Data

• Hazardous Substances Data: 23051-08-3(Hazardous Substances Data)

Usage

General Description

8-Hydroxy-2-methylquinoline-7-carboxylic acid is a chemical compound that belongs to the class of organic compounds known as hydroquinolines and derivatives. These are compounds containing a hydroquinoline moiety, which consists of a benzene ring fused to a piperidine ring, which carries a hydroxy substituent. The term 'quinoline’ is often used to refer to a large class of compounds that contain this same quinoline system. The specific details like its molecular weight, physical and chemical properties are not widely described in the scientific literature, indicating that it might not be extensively studied or it may not have widely known applications in fields such as medicine, pharmacology, or chemical production. For handling and usage of such chemical compounds, standard safety precautions for handling chemicals should be followed.

InChI:InChI=1/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)

Upstream product

• 826-81-3 2-methyl-8-quinolinol 
• 124-38-9 carbon dioxide 
• 15719-64-9 methylammonium carbonate 
• 201230-82-2 carbon monoxide 

Downstream Products

• 15599-52-7 5,7-dibromo-2-methylquinolin-8-ol 

Relevant articles and documents

X-ray and molecular modelling in fragment-based design of three small quinoline scaffolds for HIV integrase inhibitors

Crystal structures of three small molecular scaffolds based on quinoline, 2-methylquinoline-5,8-dione, 5-hydroxy-quinaldine-6-carboxylic acid and 8-hydroxy-quinaldine-7-carboxylic acid, were characterised. 5-Hydroxy- quinaldine-6-carboxylic acid was co-crystallized with cobalt(II) chloride to form a model of divalent metal cation-ligand interactions for potential HIV integrase inhibitors. Molecular docking into active site of HIV IN was also performed on 1WKN PDB file. Selected ligand-protein interactions have been found specific for active compounds. Studied structures can be used as scaffolds in fragment-based design of new potent drugs.

Synthesis, spectroscopy and computational studies of selected hydroxyquinoline carboxylic acids and their selected fluoro-, thio-, and dithioanalogues

The faster and more efficient new synthetic methodologies of crystalline hydroxyquinoline carboxylic acids and their fluoro-, thio- and dithioanalogues were elaborated. The FTIR, multinuclear NMR, UV-Vis and single crystal X-ray characteristics of the series of quinoline carboxylic acids have been determined experimentally and rationalized on the basis of DFT calculation method with B3LYP functional.

Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity

Two series of amides based on quinoline scaffold were designed and synthesized in search of photosynthesis inhibitors. The compounds were tested for their photosynthesis-inhibiting activity against Spinacia oleracea L. and Chlorella vulgaris Beij. The com