100645-45-2

Usage

Uses

Used in Biochemical Research:
P-NITROPHENYL B-D-GALACTOFURANOSIDE is used as a substrate for β-Galactofuranosidase enzymes, allowing researchers to study their activity and function. This is particularly useful in understanding the role of these enzymes in the metabolism of galactofuranose-containing organisms.
Used in Pharmaceutical Industry:
P-NITROPHENYL B-D-GALACTOFURANOSIDE is used as a potential target for the development of new antimicrobial and antifungal agents. Since galactofuranose is a key component of the cell walls of certain pathogens, inhibiting the enzymes responsible for its metabolism could lead to the development of novel treatments for infectious diseases.
Used in Diagnostic Applications:
P-NITROPHENYL B-D-GALACTOFURANOSIDE can be used as a diagnostic tool to detect the presence of β-Galactofuranosidase enzymes in clinical samples. This can help in the identification and characterization of certain pathogens, as well as in monitoring the effectiveness of treatments.
Overall, P-NITROPHENYL B-D-GALACTOFURANOSIDE is a versatile compound with applications in biochemical research, pharmaceutical development, and diagnostic applications, making it an important tool in the study of galactofuranose-containing organisms and their associated enzymes.

InChI:InChI=1/C12H15NO8/c14-5-8(15)11-9(16)10(17)12(21-11)20-7-3-1-6(2-4-7)13(18)19/h1-4,8-12,14-17H,5H2/t8-,9-,10-,11+,12-/m1/s1

Upstream product

• 108223-95-6 p-nitrophenyl 2,3,5,6-tetra-O-benzoyl-β-D-galactofuranose 
• 100-02-7 4-nitro-phenol 
• 5531-53-3 1,2,3,5,6-penta-O-acetyl-α,β-D-galactofuranose 
• 10257-28-0 D-Galactose 
• 108-24-7 acetic anhydride 
• 138811-45-7 1,2,3,5,6-penta-O-benzoyl-D-galactofuranose 
• 89202-34-6 1,2,3,5,6-penta-O-benzoyl-β-D-galactofuranoside 
• 223412-29-1 Acetic acid (2S,3S,4R)-4-acetoxy-2-((R)-1,2-diacetoxy-ethyl)-5-octyloxy-tetrahydro-furan-3-yl ester 
• 202403-49-4 n-octyl D-galactofuranoside 
• 100645-44-1 p-nitrophenyl 2,3,5,6-tetra-O-acetyl-β-D-galactofuranoside 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 7045-51-4 β-D-qalactofuranose 
• 1228460-07-8 p-nitrophenyl β-D-galactofuranosyl-(1->5)-β-D-galactofuranoside 
• 1228460-06-7 p-nitrophenyl β-D-galactofuranosyl-(1->3)-β-D-galactofuranoside 
• 1228460-08-9 p-nitrophenyl β-D-galactofuranosyl-(1->6)-β-D-galactofuranoside 
• 1228460-09-0 p-nitrophenyl β-D-galactofuranosyl-(1->2)-β-D-galactofuranosyl-(1->2)-β-D-galactofuranoside 
• 1228460-10-3 p-nitrophenyl β-D-galactofuranosyl-(1->2)-β-D-galactofuranosyl-(1->3)-β-D-galactofuranoside 
• 1228460-11-4 p-nitrophenyl β-D-galactofuranosyl-(1->6)-[β-D-galactofuranosyl-(1->2)]-β-D-galactofuranoside 
• 1604814-77-8 p-nitrophenyl β-D-galactofuranosyl-(1→2)-α-D-glucopyranoside 
• 1604814-78-9 p-nitrophenyl β-D-galactofuranosyl-(1→3)-α-D-glucopyranoside 
• 1604814-79-0 p-nitrophenyl β-D-galactofuranosyl-(1→2)-β-D-glucopyranoside 
• 1604814-80-3 p-nitrophenyl β-D-galactofuranosyl-(1→3)-β-D-glucopyranoside 
• 1604814-81-4 p-nitrophenyl β-D-galactofuranosyl-(1→6)-β-D-glucopyranoside 
• 1604814-82-5 p-nitrophenyl β-D-galactofuranosyl-(1→2)-α-D-galactopyranoside 

Relevant academic research and scientific papers

Chemo-enzymatic synthesis of p-nitrophenyl β-D-galactofuranosyl disaccharides from Aspergillus sp. fungal-type galactomannan

β-D-Galactofuranose (Galf) is a component of polysaccharides and glycoconjugates. There are few reports about the involvement of galactofuranosyltransferases and galactofuranosidases (Galf-ases) in the synthesis and degradation of galactofuranose-containing glycans. The cell walls of filamentous fungi in the genus Aspergillus include galactofuranose-containing polysaccharides and glycoconjugates, such as O-glycans, N-glycans, and fungal-type galactomannan, which are important for cell wall integrity. In this study, we investigated the synthesis of p-nitrophenyl β-D-galactofuranoside and its disaccharides by chemo-enzymatic methods including use of galactosidase. The key step was selective removal of the concomitant pyranoside by enzymatic hydrolysis to purify p-nitrophenyl β-D-galactofuranoside, a promising substrate for β-D-galactofuranosidase from Streptomyces species.

Identification and characterization of a novel galactofuranose-specific β-D-galactofuranosidase from Streptomyces species

β-D-galactofuranose (Galf) is a component of polysaccharides and glycoconjugates and its transferase has been well analyzed. However, no β-D-galactofuranosidase (Galf-ase) gene has been identified in any organism. To search for a Galf-ase gene we screened

Facile synthesis of per-O-tort-butyldimethylsilyl-β-D-galactofuranose and efficient glyeosylation via the galactofuranosyl iodide

The synthesis of crystalline per-0-TBS-β-D-galactofuranose (Aβ) as a new precursor of D-Galf units is described. Anomeric iodination by reaction with TMSI followed by in situ coupling with simple alcohols and a wide variety of glycosyl acceptors, in the absence of a promoter, was employed as a new efficient glycosylation method for the assembly of D-galactofuranosyl moieties with high β-stereoselectivity. Under the mild conditions of this reaction labile protective groups, like acetals, and furanosyl linkages are preserved.

An original chemoenzymatic route for the synthesis of β-D- galactofuranosides using an α-l-arabinofuranosidase

Galactofuranose is a widespread component of cell wall polysaccharides in bacteria, protozoa and fungi, but is totally absent in mammals. Importantly, galactofuranose is a key constituent of major cell envelope polysaccharides in pathogenic mycobacteria.

Non-natural aldofuranosides as substrates of a β-glucosidase

Based on glycosidase inhibitory activities of some known 1,4-iminoalditols, four aldofuranosides, (4-nitro)phenyl β-d-glucofuranoside, -β-d-galactofuranoside, -α-l-idofuranoside and -α-l- altrofuranoside, were identified as possible substrates of glucosid