100668-76-6

Upstream product

• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 6948-30-7 5-bromoveratralaldehyde 

Downstream Products

• 100668-77-7 (+/-)-8-hydroxyleucoperezone 
• 100668-78-8 (+/-)-leucoperezone trimethyl ether 
• 23030-39-9 1-bromo-2,3,5-trimethoxybenzene 
• 38790-14-6 1,2,5-trimethoxy-3-methylbenzene 
• 100761-40-8 (+/-)-2-(1,5-dimethyl-4-hexenyl)-3-methoxy-5-methyl-2,5-cyclohexadiene-1,4-dione <(+/-)-O-methylperezone> 
• 93092-14-9 1-bromo-5-hydroxy-2,3-dimethoxybenzene 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.

FORMAL TOTAL SYNTHESIS OF β-PIPITZOL

(+/-)-O-methylperezone (1b) was obtained by selective oxidative demethylation of (+/-)-leucoperezone trimethyl ether (4a).Compound (4a) was prepared by condensation of 2,3,5-trimethoxytoluene (5e) with 6-methyl-5-heptene-2-one, followed by reductive removal of the tertiary alcohol.The aromatic precursor 5e was prepared in four steps from 2,3-dimethoxytoluene (5a) and, alternatively, in three steps from 5-bromoveratraldehyde (6a).Racemic 1b and 4a were directly compared with the optically active molecules prepared from natural R(-)-perezone (1a).