1006686-15-2Relevant academic research and scientific papers
Substituted pyrazole fused ring derivative as well as preparation method and application thereof
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Paragraph 0185; 0217-0219, (2020/04/17)
The invention relates to the field of medicinal chemistry, and mainly relates to a compound represented by a formula I, a stereoisomer, a despinner, a tautomer, an isotope marker, NOx or a pharmaceutically acceptable salt thereof, a preparation method of the compound, and an application of the compound in preparation of a medicine for treating RET kinase mediated diseases.
QUINOLINE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE
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Paragraph 0302-0305, (2020/09/15)
A compound represented by a formula (II), an N-oxide compound, or a salt thereof: wherein R1 is a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or a halogeno group; R2 is a substituted or unsubstituted 5- to 6-membered heteroaryl group; R3 is a substituted or unsubstituted C6-10 aryl group or a substituted or unsubstituted 5- to 10-membered heteroaryl group; Y is an oxygen atom, a nitrogen atom, or a sulfur atom; A1, A2, A3 and A4 are each independently a carbon atom or a nitrogen atom, provided that two or more of A1 to A4 do not represent nitrogen atoms at the same time; X is a substituent; n represents the number of chemically acceptable substituents represented by X, and is any one of integers of 0 to 5; and when n is 2 or more, the substituents X may be the same or different from each other.
METHODS FOR USING TRIAZOLO-PYRAZINYL SOLUBLE GUANYLATE CYCLASE ACTIVATORS IN FIBROTIC DISORDERS
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Page/Page column 89; 90, (2017/12/15)
Provided are methods for treating or preventing a fibrotic disease selected from systemic sclerosis, cystic fibrosis, non-alcoholic steatohepatitis, Peyronie's disease, or interstitial lung disease; the method comprising administering a therapeutically ef
IMIDAZO-PYRAZINYL DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 38, (2016/12/22)
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated w
IMIDAZO-PYRAZINYL DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 44, (2016/12/16)
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated w
SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 34; 35, (2015/06/25)
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.
IMIDAZO-PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Page/Page column 57, (2016/04/04)
A compound of Formula II or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula II, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula II or a pharmaceutically acceptable salt thereof.
PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS
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Page/Page column 159; 160, (2014/04/18)
The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
Novel Inhibitors of Hepatitis C Virus Replication
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Page/Page column 40, (2011/05/16)
The embodiments provide compounds of the general Formula I and compound 105S, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a
2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774
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Page/Page column 29, (2011/01/05)
The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted;R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl, carbocycl
