10068-52-7Relevant articles and documents
Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides
Aikawa, Kohsuke,Morimoto, Jumpei,Okazoe, Takashi,Ono, Takahiro,Sando, Shinsuke
supporting information, p. 9386 - 9389 (2021/11/17)
Here, we investigated the effect of CH3to CF3substitution on the membrane permeability of peptides. We synthesized a series of peptides with CF3groups and corresponding nonfluorinated peptides and measured the membrane per
Preparation of fluoroalkyl imines, amines, enamines, ketones, α-amino carbonyls, and α-amino acids from primary enamine phosphonates
Palacios, Francisco,Ochoa De Retana, Ana Maria,Pascual, Sergio,Oyarzabal, Julen
, p. 8767 - 8774 (2007/10/03)
A simple method for preparation of fluoroalkyl β-enaminophosphonates 1 from alkylphosphonates 2 and perfluoroalkyl nitriles 3 is reported. Olefination reaction of functionalized phosphates 1 with aldehydes gives α,β-unsaturated imines 5. Acid hydrolysis of these fluoroalkyl derivatives 5 affords α,β-unsaturated ketones 6, while their selective reduction with hydrides leads to the formation of allylamines 7, enamines 8, and saturated ketones 9 or amines 10. Selective oxidative cleavage of the carbon-carbon double bond of allylamines 7 gives fluorinated α-amino aldehydes 12, α-amino ketones 13, or α-amino acid derivatives 14.
Untersuchungen zur Stabilitaet von N-Benzyloxycarbonyl-geschuetztem α-Trifluormethylglycinmethylester
Koksch, Beate,Ueberham,Jakubke
, p. 74 - 75 (2007/10/03)
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