177469-13-5Relevant articles and documents
Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides
Aikawa, Kohsuke,Morimoto, Jumpei,Okazoe, Takashi,Ono, Takahiro,Sando, Shinsuke
supporting information, p. 9386 - 9389 (2021/11/17)
Here, we investigated the effect of CH3to CF3substitution on the membrane permeability of peptides. We synthesized a series of peptides with CF3groups and corresponding nonfluorinated peptides and measured the membrane per
New versatile fluorinated chiral building blocks: Synthesis and reactivity of optically pure α-(fluoroalkyl)-β-sulfinylenamines
Arnone, Alberto,Bravo, Pierfrancesco,Capelli, Silvia,Fronza, Giovanni,Meille, Stefano V.,Zanda, Matteo,Cavicchio, Giancarlo,Crucianelli, Marcello
, p. 3375 - 3387 (2007/10/03)
Efficient synthesis of optically pure α-(fluoroalkyl)-β-sulfinyl enamines has been achieved by aza-Wittig reaction of triphenyliminophosphoranes with the corresponding α-fluorinated-α'-sulfinyl ketones. The title compounds 3,4 showed an overwhelming prefe