1006865-30-0

Upstream product

• 589-17-3 p-bromobenzyl chloride 
• 911855-78-2 (R)-3-methoxy-2-methyl-propan-1-ol 
• 1006865-32-2 1-bromo-4-((S)-3-methoxy-2-methyl-propoxymethyl)-benzene 
• 1006865-31-1 1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-3-(R,S)-trityloxy-methyl-piperidin-4-(R,S)-ol 

Downstream Products

• 1006865-29-7 (rac-3R,4R,5S)-1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidin-3-ol 
• 1018478-38-0 (3R,4R,5S)-1-benzyl-3-hydroxy-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidinium (S)-carboxy-phenyl-methanolate 
• 1006901-40-1 1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidin-3-ol 

Relevant academic research and scientific papers

SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS

Described are compounds of the general formula (I), and pharmaceutically acceptable salt thereof, in which R1 has the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibi

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

Phenyl piperidine derivatives for use as renin inhibitors

Compounds of the general formula and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R1 is straight-chain C1-8-alkanoyloxy, straight-chain C1-8-alkoxy, straight-chain C1-8-a