1006901-40-1

Upstream product

• 589-17-3 p-bromobenzyl chloride 
• 1006865-31-1 1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-3-(R,S)-trityloxy-methyl-piperidin-4-(R,S)-ol 
• 1006865-32-2 1-bromo-4-((S)-3-methoxy-2-methyl-propoxymethyl)-benzene 
• 1006865-30-0 1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxy-methyl)-phenyl]-3-(R,S)-trityloxymethyl-1,2,3,6-tetrahydro-pyridine 

Downstream Products

• 1006865-29-7 (rac-3R,4R,5S)-1-benzyl-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidin-3-ol 
• 1018478-38-0 (3R,4R,5S)-1-benzyl-3-hydroxy-4-[4-((S)-3-methoxy-2-methyl-propoxymethyl)-phenyl]-5-trityloxymethyl-piperidinium (S)-carboxy-phenyl-methanolate 

Relevant academic research and scientific papers

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

NITRATE ESTERS OF PIPERIDINES

The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R1, R2, R3, X, Y and Z0, and m, n, p and q have the meanings explained in more detail in