1006865-32-2Relevant academic research and scientific papers
3,4-Diarylpiperidines as potent renin inhibitors
Lacombe, Patrick,Arbour, Mélissa,Aspiotis, Renée,Cauchon, Elizabeth,Chen, Austin,Dubé, Daniel,Falgueyret, Jean-Pierre,Fournier, Pierre-André,Gallant, Michel,Grimm, Erich,Han, Yongxin,Juteau, Hélne,Liu, Suzanna,Mellon, Christophe,Ramtohul, Yeeman,Simard, Daniel,St-Jacques, René,Tsui, Gavin Chit
scheme or table, p. 1953 - 1957 (2012/04/04)
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC50, had a clean CYP 3A4 profile and displayed mic
TRISUBSTITUTED PIPERIDINES
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Page/Page column 48, (2009/05/28)
The application relates to trisubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R1, R2, R3 and X have the meanings explained in the description
4,4-DISUBSTITUTED PIPERIDINES
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Page/Page column 23, (2009/05/28)
The application relates to 4,4-disubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R2, has the meanings explained in the description, a process for their preparation
SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS
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Page/Page column 18; 23, (2009/10/30)
Described are compounds of the general formula (I), and pharmaceutically acceptable salt thereof, in which R1 has the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibi
Phenyl piperidine derivatives for use as renin inhibitors
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Page/Page column 8; 10, (2008/06/13)
Compounds of the general formula and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R1 is straight-chain C1-8-alkanoyloxy, straight-chain C1-8-alkoxy, straight-chain C1-8-a
Organic compounds
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Page/Page column 35, (2010/11/30)
The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.
Tetrahydropyridines as renin inhibitors
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Page/Page column 12, (2010/11/30)
The application relates to novel substituted tetrahydropyridines of the general formulae (I) and (II) and the salts thereof, preferably the pharmaceutically acceptable salts thereof, in which Q, T, V and W have the meanings defined in the description, to
NITRATE ESTERS OF PIPERIDINES
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Page/Page column 58, (2008/06/13)
The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R1, R2, R3, X, Y and Z0, and m, n, p and q have the meanings explained in more detail in
