1007186-13-1

Basic information

• Product Name: 3-methyl-4-[2-nitro-1-(4-methylphenyl)ethyl]-1-phenyl-5-pyrazolone
• Synonyms: 3-methyl-4-[2-nitro-1-(4-methylphenyl)ethyl]-1-phenyl-5-pyrazolone
• CAS NO: 1007186-13-1
• Molecular Weight: 337.378
• Mol File: 1007186-13-1.mol

Chemical Properties

• CAS DataBase Reference: 3-methyl-4-[2-nitro-1-(4-methylphenyl)ethyl]-1-phenyl-5-pyrazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-[2-nitro-1-(4-methylphenyl)ethyl]-1-phenyl-5-pyrazolone(1007186-13-1)
• EPA Substance Registry System: 3-methyl-4-[2-nitro-1-(4-methylphenyl)ethyl]-1-phenyl-5-pyrazolone(1007186-13-1)

Safety Data

• Hazardous Substances Data: 1007186-13-1(Hazardous Substances Data)

Upstream product

• 7559-36-6 4-methyl-β-nitrostyrene 
• 89-25-8 edaravone 

Relevant articles and documents

2-Hydroxyethylammonium acetate as a reusable and cost-effective ionic liquid for the efficient synthesis of bis(pyrazolyl)methanes and 2-pyrazolyl-1-nitroalkanes

A new and convenient method for the synthesis of bis(pyrazolyl)methanes by one-pot tandem Knoevenagel-Michael reaction of 3-methyl-1-phenyl-5-pyrazolone with aryl, heteroaryl, or alkyl aldehydes in the presence of 2-hydroxyethylammonium acetate (2-HEAA) as a task-specific ionic liquid is described. This method was also successfully applied for the synthesis of 2-pyrazolyl-1-nitroalkanes by Michael addition of 3-methyl-1-phenyl-5-pyrazolone with β-nitrostyrenes in short reaction times. The present protocol offers several advantages such as using a reusable and cost-effective ionic liquid, an environmentally benign reaction media, being amenable to scale-up and good to high yields of the products.

Catalyst free Michael addition of 3-methyl-2-pyrazolin-5-one to β-nitrostyrenes 'on water': A green protocol for facile synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol

A highly efficient and green protocol has been developed for the synthesis of 4-(1-aryl-2-nitroethyl)-3-methyl-1H-pyrazol-5-ol via Michael addition of 3-methyl-2-pyrazolin-5-one with β-nitrostyrenes under catalyst free conditions on aqueous medium. A series of 4-(1-aryl-2-nitroethyl)-3-methyl-1H- pyrazol-5-ols have been synthesized with good to excellent yield. C-alkylated product was observed exclusively with 3-methyl-2-pyrazolin-5-one without formation of N-alkylated product.

Efficient synthesis of 2-indolyl-1-nitroalkanes catalyzed by tetramethyl-tetra-3,4-pyridinoporphyrazinato copper(II) methyl sulfate

A new method for the synthesis of 2-indolyl-1-nitroalkanes from indoles and β-nitrostyrene via Michael addition catalyzed by [Cu(3,4-tmtppa)] (MeSO4)4 as a reusable catalyst under solvent-free conditions is described. This method has