1007374-13-1Relevant academic research and scientific papers
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay
Stammers, Timothy A.,Coulombe, Rene,Duplessis, Martin,Fazal, Gulrez,Gagnon, Alexandre,Garneau, Michel,Goulet, Sylvie,Jakalian, Araz,Laplante, Steven,Rancourt, Jean,Thavonekham, Bounkham,Wernic, Dominik,Kukolj, George,Beaulieu, Pierre L.
, p. 6879 - 6885 (2014/01/06)
Optimization efforts on the anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors 1 and 2 resulted in the identification of multiple structural elements that contributed to improved cell culture potency. The additive effect of these elements resulted in compound 46, an inhibitor with enzymatic (IC50) and cell culture (EC50) potencies of less than 100 nanomolar.
Viral Polymerase Inhibitors
-
, (2008/06/13)
Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.
