1007379-23-8

Upstream product

• 1415796-65-4 5-(3-fluorophenyl)-3-chloro-2-cyanopyridine 
• 85331-33-5 2-Cyano-3,5-dichloropyridine 
• 1415796-69-8 5-(3-fluorophenyl)-3-hydroxypyridine-2-carboxylic acid 
• 1668-10-6 glycinamide hydrochloride 
• 768-35-4 3-fluorophenylboronic acid 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR MODULATING DNA METHYLATION

Disclosed herein are compositions and methods for modulating DNA methylation of one or more gene promoters, treating a subject diagnosed with or suspected of having a disease or disorder characterized by DNA hypermethylation, decreasing c-myc expression, increasing desmoplakin expression, and inhibiting metastases. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

COMPOUNDS AND COMPOSITIONS FOR STABILIZING HYPOXIA INDUCIBLE FACTOR-2 ALPHA AS A METHOD FOR TREATING CANCER

Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and/or a prodrug thereof which can be used to treat cancer.