1007393-62-5

Upstream product

• 2432-12-4 2,6-dichloro-4-methylophenol 
• 945999-98-4 5-bromo-2-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridine 
• 921630-64-0 2-(2,6-dichloro-4-methyl-phenoxy)-ethanol 
• 1087352-34-8 4-(6-[2-hydroxy-ethoxy]-pyridin-3-yl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 946002-36-4 6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-5',6'-dihydro-2'H-[3,4']bipyridinyl-1',3'-dicarboxylic acid 1'-tert-butyl ester 3'-methyl ester 

Relevant academic research and scientific papers

Piperidine-based renin inhibitors: Upper chain optimization

The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor wi

RENIN INHIBITORS

The present invention relates to disubstituted piperidinyl renin inhibitor compounds having the structure (Formula I) and their use in treating cardiovascular events and renal insufficiency.

Novel Piperidine Carboxylic Acid Amide Derivatives

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these

SECONDARY AMINES AS RENIN INHIBITORS

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.