921630-64-0

Upstream product

• 96-49-1 [1,3]-dioxolan-2-one 
• 2432-12-4 2,6-dichloro-4-methylophenol 

Downstream Products

• 921630-61-7 4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-benzaldehyde 
• 945999-98-4 5-bromo-2-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridine 
• 1228766-25-3 2-(2,6-dichloro-4-methylphenoxy)ethyl methanesulfonate 
• 1253191-38-6 methyl 4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzoate 
• 1253191-37-5 4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzoic acid 
• 1253191-33-1 (4S)-1-tert-butyl 3-ethyl 4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1,3-dicarboxylate 
• 1253191-34-2 (4S)-1-(tert-butoxycarbonyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-3-carboxylic acid 
• 1253191-35-3 (4S)-tert-butyl 3-(cyclopropyl(2,3-dimethoxybenzyl)carbamoyl)-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzamido)piperidine-1-carboxylate 
• 1056555-45-3 {4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}methanol 
• 1056555-46-4 1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene 
• 1056555-02-2 methyl (2E)-2-cyano-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}acrylate 
• 1056555-50-0 methyl 2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxobutanoate 
• 1056555-51-1 methyl 2-(4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl)-3-hydroxybutanoate 
• 1056555-52-2 2-(4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl)-3-hydroxybutanoic acid 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AS INHIBITORS OF RENIN

The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to

PROCESS FOR MAKING A RENIN INHIBITOR

A salt of the compound (3'R,4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide selected from the group consisting of monoacetate salt and bis-D-tartrate salt. In one embodiment of the invention, the salt is (3',4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide monoacetate. In one embodiment of the invention, the salt is (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide bis-D-tartrate. The invention also describes a asymmetric synthesis of (3'R, 4'S)-6-[2-(2,6-Dichloro-4-methyl-phenoxy)-ethoxy]-1',2',3',4',5',6'-hexahydro-[3,4']bipyridinyl-3'-carboxylic acid [2-chloro-5-(2-methoxy-ethyl)-benzyl]-cyclopropyl-amide as a monoacetate salt or as a bis-D-tartrate salt

3,4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position oxopyridine or lsoquinolone and having the formula (I): wherein., S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

NOVEL COMPOUNDS AS INHIBITORS OF RENIN

The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to

Primary Amines as Renin Inhibitors

The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Secondary Amines as Renin Inhibitors

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

RENIN INHIBITORS

The present invention relates to biphenyl compounds of formula (I). These compounds are renin inhibitors of a non- peptidic nature and of low molecular weight. The invention further relates to a pharmaceutical composition containing said compounds, as wel

RENIN INHIBITORS

The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

Novel Piperidine Carboxylic Acid Amide Derivatives

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these