100743-63-3

Upstream product

• 67-56-1 methanol 
• 169295-51-6 (R)-1-(4-isbutylphenyl)-2-methylsulfonyloxy-1-propanone 
• 59771-24-3 4-isobutylpropiophenone 
• 169295-48-1 2-acetoxy-1-(4-isobutylphenyl)-1-propanone 
• 151647-67-5 (R)-2-hydroxy-1-(4-isobutylphenyl)-1-propanone 
• 80336-64-7 2-bromo-1-(4'-isobutyl-phenyl)-propan-1-one 
• 124-41-4 sodium methylate 
• 85277-57-2 (S)-(-)-1-(4-isobutylphenyl)-2-methylsulfonyloxy-1-propanone 

Downstream Products

• 81576-55-8 (S)-(+)-methyl 2-(4-isobutylphenyl)propionate 

Relevant academic research and scientific papers

Resolution of Secondary α-Ketoalcohols Catalyzed by Lipase and Inversioon of Stereochemistry

Several α-ketoalcohols of synthetic value were resolved using lipase as a catalyst.Lipoprotein lipase (LPL) provided the best rate of hydrolysis and kinetic differentiation.One of these optically pure α-ketoalcohol was converted to (S)-ibuprofen in good optical purity.The stereospecific inversion of (R)-alcohol to (S)-alcohol is described.Key Words Enzymatic resolution; α-Ketoalcohol; (S)-Ibuprofen

Preparation of Methyl 2-Arylpropanoates by the Reaction of 2-Hydroxypropiophenone Dimethyl Acetals with Sulfuryl Chloride in the Presence of an Amide or a Weak Base

Treatment of 2-hydroxypropiophenone dimethyl acetals (1; R=H, i-Bu, OMe, Ph, Br) with sulfuryl chloride in the presence of an amide or a weak base affords methyl 2-arylpropanoates (2) in good to excellent yields via 1,2-aryl migration of 1.The hydrolysis of 2 leads to the corresponding acids some of which are pharmaceutically important compounds having nonsteroidal anti-inflammatory and analgesic acivities.The aryl migration proceeds stereospecifically with complete inversion of configuration at the β-carbon atom.