100759-29-3

Upstream product

• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 61-90-5 L-leucine 
• 34576-15-3 N-(4-nitro-benzoyl)-L-leucine methyl ester 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 2666-93-5 (S)-Leu-OMe 

Downstream Products

• 1403587-95-0 N-(1-(2-cyano-1,2-dimethylhydrazinyl)-4-methyl-1-oxopentan-2-yl)-4-nitrobenzamide 
• 65952-91-2 N-(4-amino-benzoyl)-L-leucine 

Relevant academic research and scientific papers

N-Acylated α-Amino Acids as Novel Oral Delivery Agents for Proteins

A series of N-acylated α-amino acids were synthesized and shown to improve the oral delivery of two protein drugs, salmon calcitonin (sCT) and interferon-α.Forty-five compounds in this series were tested in vivo in rats and primates.A significant positive

Highly selective azadipeptide nitrile inhibitors for cathepsin K: Design, synthesis and activity assays

We have developed a series of azadipeptide nitriles with different P3 groups. A triaryl meta-phenyl derivative, compound 13, was not only a potent inhibitor for cathepsin K (Ki = 0.0031 nM), but also highly selective over both cathepsins B and S (～1000-fold). A protein-ligand docking study performed on the series provided a possible explanation why compound 13 could be significantly more potent than the others, especially compound 12 in the same series.

Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives

A series of N-(4-methoxy, 4-fluoro, 4-trifluoromethyl and 4-nitrobenzoyl)-L-amino acids was synthesized and their inhibitory activity towards bovine lens aldose reductase (ALR2) was tested.