N-Acylated α-Amino Acids as Novel Oral Delivery Agents for Proteins

DOI: 10.1021/jm00021a015

Source and publish data:

Journal of Medicinal Chemistry p. 4263 - 4269 (1995)

Update date:2022-08-10

Topics:

Authors:

Leone-Bay, Andrea

Santiago, Noemi

Achan, Douglas

Chaudhary, Kiran

DeMorin, Frenel

et al. et al.

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Article abstract of DOI:10.1021/jm00021a015

A series of N-acylated α-amino acids were synthesized and shown to improve the oral delivery of two protein drugs, salmon calcitonin (sCT) and interferon-α.Forty-five compounds in this series were tested in vivo in rats and primates.A significant positive

Full text of DOI:10.1021/jm00021a015

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