100760-65-4Relevant academic research and scientific papers
Straightforward and facile approach toward the n-derivatization of pyroglutamates through mitsunobu reaction: Synthesis of N-alkyl/N-acyl pyroglutamates
Panday, Sharad Kumar,Prasad, Jagdish,Pathak, Manoher Bhushan
, p. 3654 - 3661 (2011)
Pyroglutamates have been acknowledged as useful chiral synthons for the synthesis of many bioactive natural products, ACE inhibitors, and conformationally constrained peptides. Though the reactivity differences between two differential carbonyl groups have been well exploited, there is still a dearth of publications on the N-alkylation/acylation of native pyroglutamate as such, due to the relatively low reactivity of NH of pyroglutamates. In the present communication, we report for the first time a simple and efficient methodology for the N-alkylation/acylation of pyroglutamate via Mitsunobu reaction. Copyright Taylor & Francis Group, LLC.
Cationic chiral dirhodium carboxamidates are activated for lewis acid catalysis
Wang, Yuanhua,Wolf, Joffrey,Zavalij, Peter,Doyle, Michael P.
, p. 1439 - 1442 (2008/12/23)
(Chemical Equation Presented) The power of a positive charge: Oxidized chiral dirhodium carboxamidate salts increase the rate of reaction of selected aldehydes with the Danishefsky diene (hetero-Diels-Alder reaction) and with nitrones (1,3-dipolar cycload
